Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris
dc.contributor.author | Rhodes, J | |
dc.contributor.author | Abdolrasouli, A | |
dc.contributor.author | Farrer, RA | |
dc.contributor.author | Cuomo, CA | |
dc.contributor.author | Aanensen, DM | |
dc.contributor.author | Armstrong-James, D | |
dc.contributor.author | Fisher, MC | |
dc.contributor.author | Schelenz, S | |
dc.date.accessioned | 2019-09-25T11:00:16Z | |
dc.date.issued | 2018-05-31 | |
dc.description.abstract | Candida auris was first described in 2009, and it has since caused nosocomial outbreaks, invasive infections, and fungaemia across at least 19 countries on five continents. An outbreak of C. auris occurred in a specialized cardiothoracic London hospital between April 2015 and November 2016, which to date has been the largest outbreak in the UK, involving a total of 72 patients. To understand the genetic epidemiology of C. auris infection both within this hospital and within a global context, we sequenced the outbreak isolate genomes using Oxford Nanopore Technologies and Illumina platforms to detect antifungal resistance alleles and reannotate the C. auris genome. Phylogenomic analysis placed the UK outbreak in the India/Pakistan clade, demonstrating an Asian origin; the outbreak showed similar genetic diversity to that of the entire clade, and limited local spatiotemporal clustering was observed. One isolate displayed resistance to both echinocandins and 5-flucytosine; the former was associated with a serine to tyrosine amino acid substitution in the gene FKS1, and the latter was associated with a phenylalanine to isoleucine substitution in the gene FUR1. These mutations add to a growing body of research on multiple antifungal drug targets in this organism. Multiple differential episodic selection of antifungal resistant genotypes has occurred within a genetically heterogenous population across this outbreak, creating a resilient pathogen and making it difficult to define local-scale patterns of transmission and implement outbreak control measures. | en_GB |
dc.description.sponsorship | Antimicrobial Research Collaborative (ARC) | en_GB |
dc.description.sponsorship | MIT/Wellcome Trust | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.identifier.citation | Vol. 7 (1), pp. 1-12 | en_GB |
dc.identifier.doi | 10.1038/s41426-018-0045-x | |
dc.identifier.grantnumber | Early career research fellowship RSRO_54990 | en_GB |
dc.identifier.grantnumber | Fellowship | en_GB |
dc.identifier.grantnumber | K000373/1 | en_GB |
dc.identifier.grantnumber | U19AI110818 | en_GB |
dc.identifier.grantnumber | 099202 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/38883 | |
dc.language.iso | en | en_GB |
dc.publisher | Taylor & Francis | en_GB |
dc.rights | © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_GB |
dc.title | Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-09-25T11:00:16Z | |
dc.identifier.issn | 2222-1751 | |
exeter.article-number | ARTN 43 | en_GB |
dc.description | This is the final published version, also available from Taylor & Francis via the DOI in this record. | en_GB |
dc.identifier.journal | Emerging Microbes & Infections | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2018-01-24 | |
rioxxterms.funder | Natural Environment Research Council | en_GB |
rioxxterms.funder | Biotechnology and Biological Sciences Research Council | en_GB |
rioxxterms.identifier.project | NE/K014455/1 | en_GB |
rioxxterms.identifier.project | BB/L024209/1 | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2018-05-31 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-09-25T10:54:50Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-09-25T11:00:22Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA | |
rioxxterms.funder.project | e47cb48f-2869-4952-b38f-246e9b346d59 | en_GB |
rioxxterms.funder.project | 1d8e0b6f-41be-428a-8d38-d509aff73296 | en_GB |
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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.