Phthalates and asthma in children and adults: US NHANES 2007–2012
dc.contributor.author | Odebeatu, CC | |
dc.contributor.author | Taylor, T | |
dc.contributor.author | Fleming, LE | |
dc.contributor.author | J. Osborne, N | |
dc.date.accessioned | 2019-09-27T12:10:14Z | |
dc.date.issued | 2019-07-31 | |
dc.description.abstract | Environmental exposure to phthalates may contribute to an increased risk of asthma in children and adults. We aimed to assess the direction and strength of the association between urinary phthalates metabolites and current asthma in children and adults that participated in the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Data on ten urinary phthalate metabolites, self-reported questionnaires, spirometry measures, and covariates were obtained from 7765 participants (28.1% were children aged 6–17 years) taking part in the NHANES 2007–2012. Asthma was assessed using self-reported questionnaires for children and adults, and via spirometry measures for adults alone. We used crude and adjusted logistic regression models to estimate the odds ratios (ORs) and 95% confidence interval (CI) per one log10 unit change in the concentration of phthalate metabolites. We further modeled the effect modification by sex. Out of 10 metabolites, only mono-benzyl phthalate (MBzP) was positively associated with the prevalence of self-reported asthma in children, after adjusting for a range of potential confounders (odds ratio 1.54; 95% confidence interval 1.05–2.27). No significant relationship was observed for adults. The association of mono-ethyl phthalate (MEP) was modified by sex, with significantly increased odds of asthma among males [boys (2.00; 1.14–3.51); adult males (1.32; 1.04–1.69)]. While no other phthalates showed a positive relationship with current asthma in males, mono-(carboxynonyl) phthalate (MCNP) and mono-(3-carboxylpropyl) phthalate (MCPP) were inversely associated with spirometrically defined asthma in adult females. A sex-specific relationship in adults was evident when spirometry, but not self-reported measures were used to define asthma. We found no clear association between exposure to phthalates and current asthma, except for a significant relationship between MBzP metabolites and self-reported asthma in children. As a result, exposure to phthalates and asthma development and/or exacerbations remains controversial, suggesting a need for a well-designed longitudinal study. | en_GB |
dc.description.sponsorship | Commonwealth Scholarship Commission | en_GB |
dc.identifier.citation | Published online 31 July 2019 | en_GB |
dc.identifier.doi | 10.1007/s11356-019-06003-2 | |
dc.identifier.uri | http://hdl.handle.net/10871/38934 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer Nature | en_GB |
dc.rights | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_GB |
dc.subject | phthalate metabolites | en_GB |
dc.subject | mono-benzyl phthalate | en_GB |
dc.subject | childhood asthma | en_GB |
dc.subject | adult asthma | en_GB |
dc.subject | NHANES | en_GB |
dc.title | Phthalates and asthma in children and adults: US NHANES 2007–2012 | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-09-27T12:10:14Z | |
dc.identifier.issn | 0944-1344 | |
dc.description | This is the author accepted manuscript. The final version is available from Springer via the DOI in this record | en_GB |
dc.identifier.journal | Environmental Science and Pollution Research | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-07-16 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-07-31 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-09-27T12:05:52Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-09-27T12:10:18Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.