Genome-wide association studies of abdominal MRI scans identifies loci associated with liver fat and liver iron in the UK Biobank
dc.contributor.author | Wilman, H | |
dc.contributor.author | Parisinos, C | |
dc.contributor.author | Kelly, M | |
dc.contributor.author | Neubauer, S | |
dc.contributor.author | Thomas, L | |
dc.contributor.author | Bell, J | |
dc.contributor.author | Banerjee, R | |
dc.contributor.author | Yaghootkar, H | |
dc.date.accessioned | 2019-10-11T12:05:19Z | |
dc.date.issued | 2019-04-16 | |
dc.description.abstract | Excess liver iron content is common and is associated with liver diseases and metabolic diseases including diabetes, high blood pressure, and heart disease. We identified 3 genetic variants that are linked to an increased risk of developing higher liver iron content. We show that the same genetic variants are linked to higher risk of many diseases, but they may also be associated with some health advantages. Finally, we use genetic variants associated with waist-to-hip ratio as a tool to show that central obesity is causally associated with increased liver iron content. | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.identifier.citation | Vol. 70, No.1, Supplement, E135 | en_GB |
dc.identifier.doi | 10.1016/S0618-8278(19)30236-1 | |
dc.identifier.grantnumber | 17/0005594 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/39166 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights.embargoreason | Under embargo until 16 January 2020 in compliance with publisher policy | en_GB |
dc.rights | © 2019. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | Magnetic resonance imaging | en_GB |
dc.subject | iron | en_GB |
dc.subject | metabolism | en_GB |
dc.subject | metabolic syndrome | en_GB |
dc.subject | genome-wide association study | en_GB |
dc.subject | genetics | en_GB |
dc.title | Genome-wide association studies of abdominal MRI scans identifies loci associated with liver fat and liver iron in the UK Biobank | en_GB |
dc.type | Conference proceedings | en_GB |
dc.date.available | 2019-10-11T12:05:19Z | |
dc.identifier.issn | 0168-8278 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Journal of Hepatology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2019 | |
exeter.funder | ::Diabetes UK | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-04-16 | |
rioxxterms.type | Conference Paper/Proceeding/Abstract | en_GB |
refterms.dateFCD | 2019-10-11T11:54:34Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2019. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/