A de novo assembly of the common frog (Rana temporaria) transcriptome and comparison of transcription following exposure to Ranavirus and Batrachochytrium dendrobatidis
dc.contributor.author | Price, SJ | |
dc.contributor.author | Garner, TWJ | |
dc.contributor.author | Balloux, F | |
dc.contributor.author | Ruis, C | |
dc.contributor.author | Paszkiewicz, KH | |
dc.contributor.author | Moore, K | |
dc.contributor.author | Griffiths, AGF | |
dc.date.accessioned | 2019-10-22T09:18:10Z | |
dc.date.issued | 2015-06-25 | |
dc.description.abstract | Amphibians are experiencing global declines and extinctions, with infectious diseases representing a major factor. In this study we examined the transcriptional response of metamorphic hosts (common frog, Rana temporaria) to the two most important amphibian pathogens: Batrachochytrium dendrobatidis (Bd) and Ranavirus. We found strong up-regulation of a gene involved in the adaptive immune response (AP4S1) at four days post-exposure to both pathogens. We detected a significant transcriptional response to Bd, covering the immune response (innate and adaptive immunity, complement activation, and general inflammatory responses), but relatively little transcriptional response to Ranavirus. This may reflect the higher mortality rates found in wild common frogs infected with Ranavirusas opposed to Bd. These data provide a valuable genomic resource for the amphibians, contribute insight into gene expression changes after pathogen exposure, and suggest potential candidate genes for future host-pathogen research. | en_GB |
dc.description.sponsorship | European Union | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.description.sponsorship | Zoological Society of London | en_GB |
dc.description.sponsorship | European Research Council | en_GB |
dc.identifier.citation | Vol. 10 (6), article e0130500 | en_GB |
dc.identifier.doi | 10.1371/journal.pone.0130500 | |
dc.identifier.grantnumber | 327293 | en_GB |
dc.identifier.grantnumber | RG130460 | en_GB |
dc.identifier.grantnumber | 260801-BIG-IDEA | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/39291 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.rights | © 2015 Price et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | en_GB |
dc.title | A de novo assembly of the common frog (Rana temporaria) transcriptome and comparison of transcription following exposure to Ranavirus and Batrachochytrium dendrobatidis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-10-22T09:18:10Z | |
dc.description | This is the final version. Available on open access from Public Library of Science via the DOI in this record | en_GB |
dc.description | ata Availability: All raw data is available through EMBL-EBI Array Express, accession number E-MTAB-3632 | en_GB |
dc.identifier.eissn | 1932-6203 | |
dc.identifier.journal | PLoS ONE | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
pubs.euro-pubmed-id | MED:26111016 | |
dcterms.dateAccepted | 2015-05-19 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2015-06-25 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-10-22T08:59:07Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-10-22T09:18:16Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2015 Price et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited