Immunometabolic changes in Glia – a potential role in the pathophysiology of obesity and diabetes
dc.contributor.author | Robb, JL | |
dc.contributor.author | Morrissey, NA | |
dc.contributor.author | Weightman Potter, PG | |
dc.contributor.author | Smithers, HE | |
dc.contributor.author | Beall, C | |
dc.contributor.author | Ellacott, KLJ | |
dc.date.accessioned | 2019-11-25T11:53:01Z | |
dc.date.issued | 2019-11-22 | |
dc.description.abstract | Chronic low-grade inflammation is a feature of the pathophysiology of obesity and diabetes in the CNS as well as peripheral tissues. Glial cells are critical mediators of the response to inflammation in the brain. Key features of glia include their metabolic flexibility, sensitivity to changes in the CNS microenvironment, and ability to rapidly adapt their function accordingly. They are specialised cells which cooperate to promote and preserve neuronal health, playing important roles in regulating the activity of neuronal networks across the brain during different life stages. Increasing evidence points to a role of glia, most notably astrocytes and microglia, in the systemic regulation of energy and glucose homeostasis in the course of normal physiological control and during disease. Inflammation is an energetically expensive process that requires adaptive changes in cellular metabolism and, in turn, metabolic intermediates can also have immunomodulatory actions. Such “immunometabolic” changes in peripheral immune cells have been implicated in contributing to disease pathology in obesity and diabetes. This review will discuss the evidence for a role of immunometabolic changes in glial cells in the systemic regulation of energy and glucose homeostasis, and how this changes in the context of obesity and diabetes. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | European Foundation for the Study of Diabetes | en_GB |
dc.identifier.citation | Published online 22 November 2019 | en_GB |
dc.identifier.doi | 10.1016/j.neuroscience.2019.10.021 | |
dc.identifier.grantnumber | 1-INO-2016-214-A-N | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/39777 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | © 2019. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | astrocyte | en_GB |
dc.subject | microglia | en_GB |
dc.subject | inflammation | en_GB |
dc.subject | obesity | en_GB |
dc.subject | diabetes | en_GB |
dc.subject | immunometabolism | en_GB |
dc.title | Immunometabolic changes in Glia – a potential role in the pathophysiology of obesity and diabetes | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-11-25T11:53:01Z | |
dc.identifier.issn | 0306-4522 | |
dc.description | This is the final version. Available on open access from the publisher via the DOI in this record | en_GB |
dc.identifier.journal | Neuroscience | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-10-11 | |
exeter.funder | ::Medical Research Council (MRC) | en_GB |
exeter.funder | ::European Foundation for the Study of Diabetes | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-11-22 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-11-25T11:50:10Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-01-21T14:42:18Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2019. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.