Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research
Fischer, CE; Ismail, Z; Youakim, JM; et al.Creese, B; Kumar, S; Nuñez, N; Darby, RR; Di Vita, A; D’Antonio, F; de Lena, C; McGeown, WJ; Ramit, R; Rasmussen, J; Bell, J; Wang, H; Bruneau, M-A; Panegyres, PK; Lanctôt, KL; Agüera-Ortiz, L; Lyketsos, K; Cummings, J; Jeste, D; Sano, M; Devanand, DP; Sweet, RA; Ballard, C
Date: 4 February 2020
Article
Journal
Journal of Alzheimer's Disease
Publisher
IOS Press
Publisher DOI
Abstract
Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative
disorders and are associated with more rapid disease progression and increased mortality. It is
unclear to what degree existing criteria are utilized in clinical research and practice. The
International Society to Advance Alzheimer’s Research and ...
Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative
disorders and are associated with more rapid disease progression and increased mortality. It is
unclear to what degree existing criteria are utilized in clinical research and practice. The
International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup
reviewed existing criteria for psychosis in AD and related dementias. Through a series of in
person and on-line meetings, a priority checklist was devised to capture features necessary for
current research and clinical needs. PubMed, Medline and other relevant databases were
searched for relevant criteria. Consensus identified 3 sets of criteria suitable for review including
those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental
Disorders, 5th edition (DSM-5). It was concluded that existing criteria could be augmented by
including a more specific differentiation between delusions and hallucinations, address overlap
with related conditions (agitation in particular), adding the possibility of symptoms emerging in
the preclinical and prodromal phases, and building on developing research in disease biomarkers.
We propose criteria, developed to improve phenotypic classification of psychosis in AD, and
advance the research agenda in the field to improve epidemiological, biomarker and genetics
research in the field. These criteria serve as a complement to the IPA criteria for psychosis in
neurocognitive disorders.
Institute of Health Research
Collections of Former Colleges
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