A longitudinal study of epileptic seizures in Alzheimer's disease
dc.contributor.author | Baker, J | |
dc.contributor.author | Libretto, T | |
dc.contributor.author | Henley, W | |
dc.contributor.author | Zeman, A | |
dc.date.accessioned | 2020-01-13T12:33:13Z | |
dc.date.issued | 2019-12-04 | |
dc.description.abstract | The prevalence of epileptic seizures is increased in patients in the clinical stages of Alzheimer's disease (AD) when compared to age-matched cognitively normal populations. In previously reported work from the Presentation of Epileptic Seizures in Dementia (PrESIDe) study, we identified a clinical suspicion of epilepsy in between 12.75 and 28.43% of patients with AD recruited from a memory clinic. EEGs were not performed in this study. Patients with epilepsy performed similarly to patients without epilepsy on cognitive testing at the time of recruitment but were more impaired on two measures of everyday functioning [Cambridge Behavioral Inventory—Revised and Clinical Dementia Rating (CBI-R and CDR)]. On repeated testing in this 12-month follow-up study, patients in whom a suspicion of epilepsy was identified performed significantly worse on cognitive function testing (p = 0.028) in addition to maintaining a difference on the informant questionnaires (CBI-R p < 0.001, CDR p = 0.020). These findings suggest that seizures in this population could be a marker of a more rapid decline and worse prognosis. | en_GB |
dc.identifier.citation | Vol. 10, article 1266 | en_GB |
dc.identifier.doi | 10.3389/fneur.2019.01266 | |
dc.identifier.uri | http://hdl.handle.net/10871/40390 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | Copyright © 2019 Baker, Libretto, Henley and Zeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms | en_GB |
dc.subject | epilepsy | en_GB |
dc.subject | Alzheimer’s disease | en_GB |
dc.subject | dementia | en_GB |
dc.subject | prognosis | en_GB |
dc.subject | prevalence | en_GB |
dc.title | A longitudinal study of epileptic seizures in Alzheimer's disease | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-01-13T12:33:13Z | |
dc.identifier.issn | 1664-2295 | |
dc.description | This is the final version. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Frontiers in Neurology | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-11-15 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-12-04 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-01-13T12:30:43Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-01-13T12:33:19Z | |
refterms.panel | A | en_GB |
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The use, distribution or reproduction in other forums is permitted, provided the
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No use, distribution or reproduction is permitted which does not comply with these
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