Ancient diversification of eukaryotic MCM DNA replication proteins.
Richards, Thomas A
BMC Evolutionary Biology
Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within a hexamer which is believed to form the replicative helicase and which associates with the essential but non-homologous Mcm10 protein during DNA replication. In contrast Archaea generally only possess one MCM homologue which forms a homohexameric MCM helicase. In some eukaryotes Mcm8 and Mcm9 paralogues also appear to be involved in DNA replication although their exact roles are unclear.
This article is available from: http://www.biomedcentral.com/1471-2148/9/60
BMC Evolutionary Biology , 2009, Vol. 9, pp. 60 -
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