Institute of Medical Education: Recent submissions
Now showing items 86-90 of 299
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Regulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension
(Elsevier, 22 September 2020)Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide. As blood pressure regulation is influenced by multiple physiological systems, hypertension cannot be attributed ... -
An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene
(Elsevier, 3 July 2020)A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA ... -
WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension
(Wiley, 28 July 2020)Hypertension is the most prevalent health condition worldwide, affecting ~1 billion people. Gordon’s syndrome is a form of secondary hypertension that can arise due to a number of possible mutations in key genes that encode ... -
Microcirculatory dysfunction and glucose homeostasis in peritoneal dialysis
(University of Exeter Medicine, 21 September 2020)Abstract Compared with hospital based therapies, peritoneal dialysis (PD) offers many advantages to patients with end stage renal disease in terms of greater autonomy and independence in addition to its health economic ... -
Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration
(Nature Research, 3 September 2020)Determining the selective potential of antibiotics at environmental concentrations is critical for designing effective strategies to limit selection for antibiotic resistance. This study determined the minimal selective ...