The evolution of connectivity in metabolic networks.

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The evolution of connectivity in metabolic networks.

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dc.contributor.author Pfeiffer, Thomas en_US
dc.contributor.author Soyer, Orkun S. en_US
dc.contributor.author Bonhoeffer, Sebastian en_US
dc.date.accessioned 2012-05-25T14:40:40Z en_US
dc.date.accessioned 2012-09-28T18:13:20Z en_US
dc.date.accessioned 2013-03-20T12:30:14Z
dc.date.issued 2005 en_US
dc.description.abstract Processes in living cells are the result of interactions between biochemical compounds in highly complex biochemical networks. It is a major challenge in biology to understand causes and consequences of the specific design of these networks. A characteristic design feature of metabolic networks is the presence of hub metabolites such as ATP or NADH that are involved in a high number of reactions. To study the emergence of hub metabolites, we implemented computer simulations of a widely accepted scenario for the evolution of metabolic networks. Our simulations indicate that metabolic networks with a large number of highly specialized enzymes may evolve from a few multifunctional enzymes. During this process, enzymes duplicate and specialize, leading to a loss of biochemical reactions and intermediary metabolites. Complex features of metabolic networks such as the presence of hubs may result from selection of growth rate if essential biochemical mechanisms are considered. Specifically, our simulations indicate that group transfer reactions are essential for the emergence of hubs. en_US
dc.identifier.citation Vol. 3 (7), pp. 1269 - 1275 en_US
dc.identifier.doi 10.1371/journal.pbio.0030228 en_US
dc.identifier.other 04-PLBI-RA-0768R3 en_US
dc.identifier.uri http://hdl.handle.net/10036/3794 en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.url http://dx.doi.org/10.1371/journal.pbio.0030228 en_US
dc.subject Biomass en_US
dc.subject Computer Simulation en_US
dc.subject Enzymes en_US
dc.subject Escherichia coli en_US
dc.subject Evolution, Molecular en_US
dc.subject Membrane Transport Proteins en_US
dc.subject Metabolism en_US
dc.subject Multienzyme Complexes en_US
dc.subject Mutation en_US
dc.title The evolution of connectivity in metabolic networks. en_US
dc.date.available 2012-05-25T14:40:40Z en_US
dc.date.available 2012-09-28T18:13:20Z en_US
dc.date.available 2013-03-20T12:30:14Z
exeter.contacts.depositing-owner-email Soyer, Orkun <O.S.Soyer@exeter.ac.uk> en_US
exeter.contacts.owner-email Soyer, Orkun <O.S.Soyer@exeter.ac.uk> en_US
dc.description Copyright: © 2005 Pfeiffer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.description Journal Article en_US
dc.identifier.journal PLoS Biology en_GB


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