Show simple item record

dc.contributor.authorKuwahara, Hiroyukien_GB
dc.contributor.authorSoyer, Orkun S.en_GB
dc.date.accessioned2012-10-24T11:13:21Zen_GB
dc.date.accessioned2013-03-20T12:38:28Z
dc.date.issued2012en_GB
dc.description.abstractNoisy bistable dynamics in gene regulation can underlie stochastic switching and is demonstrated to be beneficial under fluctuating environments. It is not known, however, if fluctuating selection alone can result in bistable dynamics. Using a stochastic model of simple feedback networks, we apply fluctuating selection on gene expression and run in silico evolutionary simulations. We find that independent of the specific nature of the environment-fitness relationship, the main outcome of fluctuating selection is the evolution of increased evolvability in the network; system parameters evolve toward a nonlinear regime where phenotypic diversity is increased and small changes in genotype cause large changes in expression level. In the presence of noise, the evolution of increased nonlinearity results in the emergence and maintenance of bistability. Our results provide the first direct evidence that bistability and stochastic switching in a gene regulatory network can emerge as a mechanism to cope with fluctuating environments. They strongly suggest that such emergence occurs as a byproduct of evolution of evolvability and exploitation of noise by evolution.en_GB
dc.identifier.citationVol. 8, article 564en_GB
dc.identifier.doi10.1038/msb.2011.98en_GB
dc.identifier.urihttp://hdl.handle.net/10036/3898en_GB
dc.language.isoenen_GB
dc.relation.urlhttp://dx.doi.org/10.1038/msb.2011.98en_GB
dc.subjectAnimalsen_GB
dc.subjectBiological Evolutionen_GB
dc.subjectComputer Simulationen_GB
dc.subjectEnvironmenten_GB
dc.subjectGene Regulatory Networksen_GB
dc.subjectGene-Environment Interactionen_GB
dc.subjectGenomic Instabilityen_GB
dc.subjectGenotypeen_GB
dc.subjectHumansen_GB
dc.subjectMutationen_GB
dc.subjectPhenotypeen_GB
dc.subjectStochastic Processesen_GB
dc.subjectBiological adaptationen_GB
dc.subjectBiological modelsen_GB
dc.subjectTheoretical modelsen_GB
dc.subjectMolecular evolutionen_GB
dc.subjectPhysiological feedbacken_GB
dc.subjectEnvironmental fluctuationsen_GB
dc.subjectGenetic selectionen_GB
dc.subjectNoiseen_GB
dc.subjectPhenotypic variabilityen_GB
dc.subjectStochastic switchingen_GB
dc.titleBistability in feedback circuits as a byproduct of evolution of evolvabilityen_GB
dc.typeArticleen_GB
dc.date.available2012-10-24T11:13:21Zen_GB
dc.date.available2013-03-20T12:38:28Z
dc.identifier.issn1744-4292en_GB
exeter.article-number564en_GB
exeter.place-of-publicationEnglanden_GB
dc.descriptionCopyright © 2008 Nature Publishing Groupen_GB
dc.identifier.journalMolecular Systems Biologyen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record