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dc.contributor.authorEdwards, Kieron D.en_GB
dc.contributor.authorAkman, Ozgur E.en_GB
dc.contributor.authorKnox, Kirstenen_GB
dc.contributor.authorLumsden, Peter J.en_GB
dc.contributor.authorThomson, Adrian W.en_GB
dc.contributor.authorBrown, Paul E.en_GB
dc.contributor.authorPokhilko, Alexandraen_GB
dc.contributor.authorKozma-Bognar, Laszloen_GB
dc.contributor.authorNagy, Ferencen_GB
dc.contributor.authorRand, David A.en_GB
dc.contributor.authorMillar, Andrew J.en_GB
dc.date.accessioned2013-03-12T15:57:50Zen_GB
dc.date.accessioned2013-03-20T12:23:50Z
dc.date.issued2010en_GB
dc.description.abstractThe circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecular rhythms to track multiple phases of the external cycle. Clear dawn- and dusk-tracking rhythms illustrate the flexibility of timing in Ipomoea nil. Molecular clock components in Arabidopsis thaliana showed complex, photoperiod-dependent regulation, which was analysed by comparison with three contrasting models. A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening-expressed clock genes showed photoperiod-dependent dusk sensitivity, as predicted by the three-loop model, whereas the one- and two-loop models tracked dawn and dusk, respectively. Output genes for starch degradation achieved dusk-tracking expression through light regulation, rather than a dusk-tracking rhythm. Model analysis predicted which biochemical processes could be manipulated to extend dusk tracking. Our results reveal how an operating principle of biological regulators applies specifically to the plant circadian clock.en_GB
dc.identifier.citationVol. 6, article 424en_GB
dc.identifier.doi10.1038/msb.2010.81en_GB
dc.identifier.urihttp://hdl.handle.net/10036/4467en_GB
dc.language.isoenen_GB
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://dx.doi.org/10.1038/msb.2010.81en_GB
dc.subjectArabidopsisen_GB
dc.subjectCLOCK Proteinsen_GB
dc.subjectCircadian Clocksen_GB
dc.subjectGene Regulatory Networksen_GB
dc.subjectGenes, Reporteren_GB
dc.subjectIpomoea nilen_GB
dc.subjectModels, Biologicalen_GB
dc.subjectPhotoperioden_GB
dc.subjectSystems Biologyen_GB
dc.titleQuantitative analysis of regulatory flexibility under changing environmental conditionsen_GB
dc.typeArticleen_GB
dc.date.available2013-03-12T15:57:50Zen_GB
dc.date.available2013-03-20T12:23:50Z
dc.identifier.issn1744-4292en_GB
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.en_GB
dc.identifier.journalMolecular Systems Biologyen_GB


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