Role of T cells in innate and adaptive immunity against Murine Burkholderia pseudomallei infection

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Role of T cells in innate and adaptive immunity against Murine Burkholderia pseudomallei infection

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dc.contributor.author Haque, Ashraful en_GB
dc.contributor.author Easton, Anna en_GB
dc.contributor.author Smith, Debbie en_GB
dc.contributor.author O'Garra, Anne en_GB
dc.contributor.author Van Rooijen, Nico en_GB
dc.contributor.author Lertmemongkolchai, Ganjana en_GB
dc.contributor.author Titball, Richard W. en_GB
dc.contributor.author Bancroft, Gregory J. en_GB
dc.contributor.department University of Exeter (at the time of publication Richard Titball was at the Defence, Science and Technology Laboratory, Salisbury, UK); London School of Hygiene and Tropical Medicine; National Institute for Medical Research, Mill Hill, London; Vrije Universiteit, Amsterdam; Khon Kaen University, Khon Kaen, Thailand en_GB
dc.date.accessioned 2009-01-05T17:01:25Z en_GB
dc.date.accessioned 2011-01-25T11:47:03Z en_US
dc.date.accessioned 2013-03-20T14:48:43Z
dc.date.issued 2006 en_GB
dc.description.abstract Antigen-specific T cells are important sources of interferon (IFN)–γ for acquired immunity to intracellular pathogens, but they can also produce IFN-γ directly via a “bystander” activation pathway in response to proinflammatory cytokines. We investigated the in vivo role of cytokine- versus antigen-mediated T cell activation in resistance to the pathogenic bacterium Burkholderia pseudomallei. IFN-γ, interleukin (IL)–12, and IL-18 were essential for initial bacterial control in infected mice. B. pseudomallei infection rapidly generated a potent IFN-γ response from natural killer (NK) cells, NK T cells, conventional T cells, and other cell types within 16 h after infection, in an IL-12– and IL-18–dependent manner. However, early T cell– and NK cell–derived IFN-γ responses were functionally redundant in cell depletion studies, with IFN-γ produced by other cell types, such as major histocompatibility complex class IIint F4/80+ macrophages being sufficient for initial resistance. In contrast, B. pseudomallei–specific CD4+ T cells played an important role during the later stage of infection. Thus, the T cell response to primary B. pseudomallei infection is biphasic, an early cytokine-induced phase in which T cells appear to be functionally redundant for initial bacterial clearance, followed by a later antigen-induced phase in which B. pseudomallei–specific T cells, in particular CD4+ T cells, are important for host resistance. en_GB
dc.identifier.citation 193 (3), pp. 370-379 en_GB
dc.identifier.doi 10.1086/498983 en_GB
dc.identifier.uri http://hdl.handle.net/10036/47046 en_GB
dc.language.iso en en_GB
dc.publisher Published by University of Chicago Press for the Infectious Diseases Society of America en_GB
dc.relation.url http://dx.doi.org/10.1086/498983 en_GB
dc.relation.url http://www.journals.uchicago.edu/doi/abs/10.1086/498983 en_GB
dc.title Role of T cells in innate and adaptive immunity against Murine Burkholderia pseudomallei infection en_GB
dc.type Article en_GB
dc.date.available 2009-01-05T17:01:25Z en_GB
dc.date.available 2011-01-25T11:47:03Z en_US
dc.date.available 2013-03-20T14:48:43Z
dc.identifier.issn 0022-1899 en_GB
dc.identifier.issn 1537-6613 en_GB
dc.description © 2005 by the Infectious Diseases Society of America. All rights reserved. en_GB
dc.identifier.journal The Journal of Infectious Diseases en_GB


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