dc.contributor.author | Mayers, Carl | en_GB |
dc.contributor.author | Duffield, Melanie | en_GB |
dc.contributor.author | Rowe, Sonya | en_GB |
dc.contributor.author | Miller, Julie | en_GB |
dc.contributor.author | Lingard, Bryan | en_GB |
dc.contributor.author | Hayward, Sarah | en_GB |
dc.contributor.author | Titball, Richard W. | en_GB |
dc.contributor.department | University of Exeter (at the time of publication Richard Titball was at the Defence, Science and Technology Laboratory, Salisbury, UK); Defence, Science and Technology Laboratory | en_GB |
dc.date.accessioned | 2009-01-08T16:35:31Z | en_GB |
dc.date.accessioned | 2011-01-25T11:46:56Z | en_GB |
dc.date.accessioned | 2013-03-20T14:48:05Z | |
dc.date.issued | 2003-10-10 | en_GB |
dc.description.abstract | Many vaccines have been developed from live attenuated forms of bacterial pathogens or from killed bacterial cells. However, an increased awareness of the potential for transient side-effects following vaccination has prompted an increased emphasis on the use of sub-unit vaccines, rather than those based on whole bacterial cells. The identification of vaccine sub-units is often a lengthy process and bioinformatics approaches have recently been used to identify candidate protein vaccine antigens. Such methods ultimately offer the promise of a more rapid advance towards preclinical studies with vaccines. We have compared the properties of known bacterial vaccine antigens against randomly selected proteins and identified differences in the make-up of these two groups. A computer algorithm that exploits these differences allows the identification of potential vaccine antigen candidates from pathogenic bacteria on the basis of their amino acid composition, a property inherently associated with sub-cellular location. | en_GB |
dc.identifier.citation | 4 (5), pp. 468-478 | en_GB |
dc.identifier.doi | 10.1002/cfg.319 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10036/47200 | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Hindawi Publishing Corporation | en_GB |
dc.subject | vaccine design | en_GB |
dc.subject | vaccine antigens | en_GB |
dc.subject | genome sequence | en_GB |
dc.title | Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2009-01-08T16:35:31Z | en_GB |
dc.date.available | 2011-01-25T11:46:56Z | en_GB |
dc.date.available | 2013-03-20T14:48:05Z | |
dc.identifier.issn | 1531-6912 | en_GB |
dc.identifier.issn | 1532-6268 | en_GB |
dc.description | Copyright © 2003 John Wiley & Sons, Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.identifier.journal | Comparative and Functional Genomics | en_GB |