Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes
Gloyn, Anna L.
Public Library of Science
The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in animal models cause divergent phenotypes to those seen in man. We hypothesised that some differences may arise from variation in the expression profile of alternatively processed isoforms between species.
addresses: Institute of Biomedical and Clinical Sciences, Peninsula Medical School, University of Exeter, Exeter, United Kingdom. L.W.Harries@exeter.ac.uk
notes: PMCID: PMC2773013
types: Journal Article; Research Support, Non-U.S. Gov't
Copyright: © 2009 Harries et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PLoS One, 2009, Vol. 4, Issue 11, pp. e7855 -
Place of publication