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Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes

dc.contributor.authorHarries, LW
dc.contributor.authorBrown, JE
dc.contributor.authorGloyn, Anna L.
dc.date.accessioned2013-07-04T09:44:22Z
dc.date.issued2009
dc.description.abstractThe HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in animal models cause divergent phenotypes to those seen in man. We hypothesised that some differences may arise from variation in the expression profile of alternatively processed isoforms between species.en_GB
dc.identifier.citationPLoS One, 2009, Vol. 4, Issue 11, pp. e7855 -en_GB
dc.identifier.doi10.1371/journal.pone.0007855
dc.identifier.urihttp://hdl.handle.net/10871/11525
dc.language.isoenen_GB
dc.publisherPublic Library of Scienceen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19924231en_GB
dc.relation.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007855en_GB
dc.subjectAdulten_GB
dc.subjectAlternative Splicingen_GB
dc.subjectAnimalsen_GB
dc.subjectFemaleen_GB
dc.subjectGene Expression Profilingen_GB
dc.subjectGene Expression Regulationen_GB
dc.subjectHepatocyte Nuclear Factor 1-alphaen_GB
dc.subjectHepatocyte Nuclear Factor 1-betaen_GB
dc.subjectHepatocyte Nuclear Factor 4en_GB
dc.subjectHumansen_GB
dc.subjectIslets of Langerhansen_GB
dc.subjectMaleen_GB
dc.subjectMiceen_GB
dc.subjectMice, Inbred BALB Cen_GB
dc.subjectMiddle Ageden_GB
dc.subjectRatsen_GB
dc.subjectRats, Wistaren_GB
dc.subjectSpecies Specificityen_GB
dc.titleSpecies-specific differences in the expression of the HNF1A, HNF1B and HNF4A genesen_GB
dc.typeArticleen_GB
dc.date.available2013-07-04T09:44:22Z
exeter.place-of-publicationUnited States
dc.descriptionaddresses: Institute of Biomedical and Clinical Sciences, Peninsula Medical School, University of Exeter, Exeter, United Kingdom. L.W.Harries@exeter.ac.uken_GB
dc.descriptionnotes: PMCID: PMC2773013en_GB
dc.descriptiontypes: Journal Article; Research Support, Non-U.S. Gov'ten_GB
dc.descriptionCopyright: © 2009 Harries et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_GB
dc.identifier.journalPLoS Oneen_GB


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