Ion channel noise shapes the electrical activity of endocrine cells
dc.contributor.author | Richards, DM | |
dc.contributor.author | Walker, JJ | |
dc.contributor.author | Tabak, J | |
dc.date.accessioned | 2020-04-28T13:33:01Z | |
dc.date.issued | 2020-04-06 | |
dc.description.abstract | Endocrine cells in the pituitary gland typically display either spiking or bursting electrical activity, which is related to the level of hormone secretion. Recent work, which combines mathematical modelling with dynamic clamp experiments, suggests the difference is due to the presence or absence of a few large-conductance potassium channels. Since endocrine cells only contain a handful of these channels, it is likely that stochastic effects play an important role in the pattern of electrical activity. Here, for the first time, we explicitly determine the effect of such noise by studying a mathematical model that includes the realistic noisy opening and closing of ion channels. This allows us to investigate how noise affects the electrical activity, examine the origin of spiking and bursting, and determine which channel types are responsible for the greatest noise. Further, for the first time, we address the role of cell size in endocrine cell electrical activity, finding that larger cells typically display more bursting, while the smallest cells almost always only exhibit spiking behaviour. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.identifier.citation | Vol. 16 (4), article e1007769 | en_GB |
dc.identifier.doi | 10.1371/journal.pcbi.1007769 | |
dc.identifier.grantnumber | MR/P022405/1 | en_GB |
dc.identifier.grantnumber | MR/N008936/1 | en_GB |
dc.identifier.grantnumber | EP/N014391/1 | en_GB |
dc.identifier.grantnumber | WT105618MA | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/120834 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science for International Society for Computational Biology (ISCB) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/32251433 | en_GB |
dc.rights | © 2020 Richards et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.title | Ion channel noise shapes the electrical activity of endocrine cells | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-04-28T13:33:01Z | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the final version. Available on open access from Public Library of Science via the DOI in this record | en_GB |
dc.description | Data Availability: All relevant data are within the manuscript and its Supporting Information files. | en_GB |
dc.identifier.eissn | 1553-7358 | |
dc.identifier.journal | PLoS Computational Biology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-03-03 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-04-06 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-04-28T13:31:00Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-04-28T13:33:07Z | |
refterms.panel | B | en_GB |
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Except where otherwise noted, this item's licence is described as © 2020 Richards et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.