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dc.contributor.authorHarrison, JW
dc.contributor.authorTallapragada, DSP
dc.contributor.authorBaptist, A
dc.contributor.authorSharp, SA
dc.contributor.authorBhaskar, S
dc.contributor.authorJog, KS
dc.contributor.authorPatel, KA
dc.contributor.authorWeedon, MN
dc.contributor.authorChandak, GR
dc.contributor.authorYajnik, CS
dc.contributor.authorOram, RA
dc.date.accessioned2020-06-18T13:31:55Z
dc.date.issued2020-06-11
dc.description.abstractType 1 diabetes (T1D) is a significant problem in Indians and misclassification of T1D and type 2 diabetes (T2D) is a particular problem in young adults in this population due to the high prevalence of early onset T2D at lower BMI. We have previously shown a genetic risk score (GRS) can be used to discriminate T1D from T2D in Europeans. We aimed to test the ability of a T1D GRS to discriminate T1D from T2D and controls in Indians. We studied subjects from Pune, India of Indo-European ancestry; T1D (n = 262 clinically defined, 200 autoantibody positive), T2D (n = 345) and controls (n = 324). We used the 9 SNP T1D GRS generated in Europeans and assessed its ability to discriminate T1D from T2D and controls in Indians. We compared Indians with Europeans from the Wellcome Trust Case Control Consortium study; T1D (n = 1963), T2D (n = 1924) and controls (n = 2938). The T1D GRS was discriminative of T1D from T2D in Indians but slightly less than in Europeans (ROC AUC 0.84 v 0.87, p < 0.0001). HLA SNPs contributed the majority of the discriminative power in Indians. A T1D GRS using SNPs defined in Europeans is discriminative of T1D from T2D and controls in Indians. As with Europeans, the T1D GRS may be useful for classifying diabetes in Indians.en_GB
dc.description.sponsorshipDiabetes UKen_GB
dc.description.sponsorshipCouncil of Scientific and Industrial Research (CSIR), Indiaen_GB
dc.identifier.citationVol. 10, article 9450en_GB
dc.identifier.doi10.1038/s41598-020-65317-1
dc.identifier.urihttp://hdl.handle.net/10871/121521
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.rights© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_GB
dc.titleType 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in Indiaen_GB
dc.typeArticleen_GB
dc.date.available2020-06-18T13:31:55Z
exeter.article-number9450en_GB
dc.descriptionThis is the final version. Available on open access from Nature Research via the DOI in this recorden_GB
dc.descriptionData availability: In order to access data generated or used in this study not contained in the manuscript please contact corresponding authors.en_GB
dc.identifier.eissn2045-2322
dc.identifier.journalScientific Reportsen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-03-02
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-03-02
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-06-18T13:29:41Z
refterms.versionFCDVoR
refterms.dateFOA2020-06-18T13:32:01Z
refterms.panelAen_GB
refterms.depositExceptionpublishedGoldOA


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© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.