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dc.contributor.authorDey, P
dc.contributor.authorTabish, TA
dc.contributor.authorMosca, S
dc.contributor.authorPalombo, F
dc.contributor.authorMatousek, P
dc.contributor.authorStone, N
dc.date.accessioned2020-07-23T08:50:44Z
dc.date.issued2020-03-12
dc.description.abstractOptical theranostic applications demand near-infrared (NIR) localized surface plasmon resonance (LSPR) and maximized electric field at nanosurfaces and nanojunctions, aiding diagnosis via Raman or optoacoustic imaging, and photothermal-based therapies. To this end, multiple permutations and combinations of plasmonic nanostructures and molecular “glues” or linkers are employed to obtain nanoassemblies, such as nanobranches and core–satellite morphologies. An advanced nanoassembly morphology comprising multiple linear tentacles anchored onto a spherical core is reported here. Importantly, this core-multi-tentacle-nanoassembly (CMT) benefits from numerous plasmonic interactions between multiple 5 nm gold nanoparticles (NPs) forming each tentacle as well as tentacle to core (15 nm) coupling. This results in an intense LSPR across the “biological optical window” of 650−1100 nm. It is shown that the combined interactions are responsible for the broadband LSPR and the intense electric field, otherwise not achievable with core–satellite morphologies. Further the sub 80 nm CMTs boosted NIR-surface-enhanced Raman scattering (SERS), with detection of SERS labels at 47 × 10-9 m, as well as lower toxicity to noncancerous cell lines (human fibroblast Wi38) than observed for cancerous cell lines (human breast cancer MCF7), presents itself as an attractive candidate for use as biomedical theranostics agents.en_GB
dc.description.sponsorshipEPSRCen_GB
dc.identifier.citationVol. 16 (10), 1906780en_GB
dc.identifier.doi10.1002/smll.201906780
dc.identifier.grantnumberEP/R020965/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/122093
dc.language.isoenen_GB
dc.publisherWileyen_GB
dc.rights© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectbranched polymersen_GB
dc.subjectbroadband NIR absorbanceen_GB
dc.subjectcell toxicityen_GB
dc.subjectcore-satellitesen_GB
dc.subjectplasmonic nanoassembliesen_GB
dc.subjectsurface-enhanced raman scattering (SERS)en_GB
dc.titlePlasmonic Nanoassemblies: Tentacles Beat Satellites for Boosting Broadband NIR Plasmon Coupling Providing a Novel Candidate for SERS and Photothermal Therapyen_GB
dc.typeArticleen_GB
dc.date.available2020-07-23T08:50:44Z
dc.identifier.issn1613-6810
dc.descriptionThis is the final version. Available from Wiley via the DOI in this record. en_GB
dc.identifier.journalSmallen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2020-01-30
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2020-03-12
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2020-07-23T08:46:25Z
refterms.versionFCDVoR
refterms.dateFOA2020-07-23T08:50:48Z
refterms.panelBen_GB


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© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's licence is described as © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.