Background: Lewy body dementia, comprising both dementia with Lewy bodies and
Parkinson’s disease dementia, is challenging to manage because of a complex symptom
profile and lack of clear evidence-based management guidelines.
Objectives: We assessed the feasibility of undertaking a cluster randomised study of
the introduction ...
Background: Lewy body dementia, comprising both dementia with Lewy bodies and
Parkinson’s disease dementia, is challenging to manage because of a complex symptom
profile and lack of clear evidence-based management guidelines.
Objectives: We assessed the feasibility of undertaking a cluster randomised study of
the introduction of an evidence-based management toolkit for Lewy body dementia,
assessing outcomes for patients and carers as secondary measures.
Methods: We randomised 23 memory/dementia, movement disorder or non-specialist
secondary care services to the management toolkit or usual care. People with dementia
with Lewy bodies or Parkinson’s disease dementia underwent assessments of cognition,
motor and neuropsychiatric symptoms and global outcome at baseline, 3 and 6 months.
Healthcare, personal and social care costs, and carer-related outcomes of carer stress,
depression and anxiety were also examined.
Results: 131 participants were recruited (target 120), for whom 6-month data were
available on 108 (83%). There was a benefit of being in the intervention arm for carers
(reduced Zarit burden scale (p<0.01), reduced depressive symptoms (p<0.05)), who also
reported less marked patient deterioration on the global outcome measure (p=0<.05).
There were no significant differences in other outcomes or in costs between groups.
Conclusions: The introduction of an evidence-based management toolkit for Lewy body
dementia was feasible and associated with some benefits, especially for carers.