Introduction of a management toolkit for Lewy body dementia: A pilot cluster randomised trial
dc.contributor.author | O'Brien, JT | |
dc.contributor.author | McKeith, IG | |
dc.contributor.author | Thomas, AJ | |
dc.contributor.author | Bamford, C | |
dc.contributor.author | Vale, L | |
dc.contributor.author | Hill, S | |
dc.contributor.author | Allan, L | |
dc.contributor.author | Finch, T | |
dc.contributor.author | McNally, R | |
dc.contributor.author | Hayes, L | |
dc.contributor.author | Surendranathan, A | |
dc.contributor.author | Kane, JPM | |
dc.contributor.author | Dunn, S | |
dc.contributor.author | Bentley, A | |
dc.contributor.author | Barker, S | |
dc.contributor.author | Mason, J | |
dc.contributor.author | Burn, D | |
dc.contributor.author | Taylor, J-P | |
dc.date.accessioned | 2020-09-02T14:10:55Z | |
dc.date.issued | 2020-09-22 | |
dc.description.abstract | Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is challenging to manage because of a complex symptom profile and lack of clear evidence-based management guidelines. Objectives: We assessed the feasibility of undertaking a cluster randomised study of the introduction of an evidence-based management toolkit for Lewy body dementia, assessing outcomes for patients and carers as secondary measures. Methods: We randomised 23 memory/dementia, movement disorder or non-specialist secondary care services to the management toolkit or usual care. People with dementia with Lewy bodies or Parkinson’s disease dementia underwent assessments of cognition, motor and neuropsychiatric symptoms and global outcome at baseline, 3 and 6 months. Healthcare, personal and social care costs, and carer-related outcomes of carer stress, depression and anxiety were also examined. Results: 131 participants were recruited (target 120), for whom 6-month data were available on 108 (83%). There was a benefit of being in the intervention arm for carers (reduced Zarit burden scale (p<0.01), reduced depressive symptoms (p<0.05)), who also reported less marked patient deterioration on the global outcome measure (p=0<.05). There were no significant differences in other outcomes or in costs between groups. Conclusions: The introduction of an evidence-based management toolkit for Lewy body dementia was feasible and associated with some benefits, especially for carers. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Published online 22 September 2020 | en_GB |
dc.identifier.doi | 10.1002/mds.28282 | |
dc.identifier.grantnumber | DTC-RP-PG-0311-12001 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/122684 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley / International Parkinson and Movement Disorder Society | en_GB |
dc.rights | © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |
dc.subject | Lewy body dementia | en_GB |
dc.subject | clinical trial | en_GB |
dc.subject | management | en_GB |
dc.subject | dementia with Lewy bodies | en_GB |
dc.subject | Parkinson’s disease dementia | en_GB |
dc.title | Introduction of a management toolkit for Lewy body dementia: A pilot cluster randomised trial | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-09-02T14:10:55Z | |
dc.identifier.issn | 0885-3185 | |
dc.description | This is the final version. Available on open access from Wiley via the DOI in this record | en_GB |
dc.identifier.journal | Movement Disorders | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-08-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-08-17 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-09-02T10:52:50Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-09-23T14:25:03Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.