Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study
dc.contributor.author | Drake, TM | |
dc.contributor.author | Docherty, AB | |
dc.contributor.author | Harrison, EM | |
dc.contributor.author | Quint, JK | |
dc.contributor.author | Adamali, H | |
dc.contributor.author | Agnew, S | |
dc.contributor.author | Babu, S | |
dc.contributor.author | Barber, CM | |
dc.contributor.author | Barratt, S | |
dc.contributor.author | Bendstrup, E | |
dc.contributor.author | Bianchi, S | |
dc.contributor.author | Castillo Villegas, D | |
dc.contributor.author | Chaudhuri, N | |
dc.contributor.author | Chua, F | |
dc.contributor.author | Coker, R | |
dc.contributor.author | Chang, W | |
dc.contributor.author | Cranshaw, A | |
dc.contributor.author | Crowley, LE | |
dc.contributor.author | Dosanjh, D | |
dc.contributor.author | Fiddler, CA | |
dc.contributor.author | Forrest, IA | |
dc.contributor.author | George, PM | |
dc.contributor.author | Gibbons, MA | |
dc.contributor.author | Groom, K | |
dc.contributor.author | Haney, S | |
dc.contributor.author | Hart, SP | |
dc.contributor.author | Heiden, E | |
dc.contributor.author | Henry, M | |
dc.contributor.author | Ho, L-P | |
dc.contributor.author | Hoyles, RK | |
dc.contributor.author | Hutchinson, J | |
dc.contributor.author | Hurley, K | |
dc.contributor.author | Jones, MG | |
dc.contributor.author | Jones, S | |
dc.contributor.author | Kokosi, M | |
dc.contributor.author | Kreuter, M | |
dc.contributor.author | Mackay, LS | |
dc.contributor.author | Mahendran, S | |
dc.contributor.author | Margaritopoulos, G | |
dc.contributor.author | Molina-Molina, M | |
dc.contributor.author | Molyneaux, PL | |
dc.contributor.author | O'Brien, A | |
dc.contributor.author | O'Reilly, K | |
dc.contributor.author | Packham, A | |
dc.contributor.author | Parfrey, H | |
dc.contributor.author | Poletti, V | |
dc.contributor.author | Porter, JC | |
dc.contributor.author | Renzoni, E | |
dc.contributor.author | Rivera-Ortega, P | |
dc.contributor.author | Russell, A-M | |
dc.contributor.author | Saini, G | |
dc.contributor.author | Spencer, LG | |
dc.contributor.author | Stella, GM | |
dc.contributor.author | Stone, H | |
dc.contributor.author | Sturney, S | |
dc.contributor.author | Thickett, D | |
dc.contributor.author | Thillai, M | |
dc.contributor.author | Wallis, T | |
dc.contributor.author | Ward, K | |
dc.contributor.author | Wells, AU | |
dc.contributor.author | West, A | |
dc.contributor.author | Wickremasinghe, M | |
dc.contributor.author | Woodhead, F | |
dc.contributor.author | Hearson, G | |
dc.contributor.author | Howard, L | |
dc.contributor.author | Baillie, JK | |
dc.contributor.author | Openshaw, PJM | |
dc.contributor.author | Semple, MG | |
dc.contributor.author | Stewart, I | |
dc.contributor.author | Jenkins, RG | |
dc.date.accessioned | 2020-10-05T14:17:39Z | |
dc.date.issued | 2020-10-02 | |
dc.description.abstract | Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 2.27, 1.39−3.71). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.identifier.citation | Published Online 2nd October 2020 | en_GB |
dc.identifier.doi | 10.1164/rccm.202007-2794oc | |
dc.identifier.uri | http://hdl.handle.net/10871/123098 | |
dc.language.iso | en | en_GB |
dc.publisher | American Thoracic Society | en_GB |
dc.rights | Copyright © 2020 by the American Thoracic Society . This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 | en_GB |
dc.subject | COVID-19 | en_GB |
dc.subject | IPF | en_GB |
dc.subject | ILD | en_GB |
dc.subject | Obesity | en_GB |
dc.subject | Lung Function | en_GB |
dc.subject | hospitalisation | en_GB |
dc.title | Outcome of hospitalization for COVID-19 in patients with interstitial lung disease: an international multicenter study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-10-05T14:17:39Z | |
dc.identifier.issn | 1073-449X | |
exeter.article-number | rccm.202007-2794OC | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record | en_GB |
dc.description | This article has an online data supplement, which is accessible from this issue’s table of content online at www.atsjournals.org | en_GB |
dc.identifier.journal | American Journal of Respiratory and Critical Care Medicine | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2020-10-02 | |
rioxxterms.version | AM | en_GB |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-10-05T13:40:38Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-10-05T14:17:45Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as Copyright © 2020 by the American Thoracic Society . This article is open access and distributed under the terms of the Creative Commons
Attribution Non-Commercial No Derivatives License 4.0