Predicting the Refractive Index of Tissue Models Using Light Scattering Spectroscopy
dc.contributor.author | Bailey, M | |
dc.contributor.author | Gardner, B | |
dc.contributor.author | Alunni Cardinali, M | |
dc.contributor.author | Caponi, S | |
dc.contributor.author | Fioretto, D | |
dc.contributor.author | Stone, N | |
dc.contributor.author | Palombo, F | |
dc.date.accessioned | 2020-12-08T09:02:47Z | |
dc.date.issued | 2020-12-15 | |
dc.description.abstract | In this work, we report the application of Raman microspectroscopy for analysis of the refractive index of a range of tissue phantoms. Using both a custom-developed setup with visible laser source and a commercial micro-spectrometer with near infrared laser, we measured the Raman spectra of gelatin hydrogels at various concentrations. By building a calibration curve from measured refractometry data and Raman scattering intensity for different vibrational modes of the hydrogel, we were able to predict the refractiveindices of the gels from their Raman spectra.This work highlights the importance of a correlative approach through Brillouin-Raman microspectroscopy for the mechano-chemical analysis of biologically relevant samples. | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.description.sponsorship | Cancer Research UK | en_GB |
dc.identifier.citation | Published online 15 December 2020 | en_GB |
dc.identifier.doi | 10.1177/0003702820984482 | |
dc.identifier.grantnumber | EP/M028739/1 | en_GB |
dc.identifier.grantnumber | NS/A000063/1 | en_GB |
dc.identifier.grantnumber | CA16124 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/123947 | |
dc.language.iso | en | en_GB |
dc.publisher | SAGE Publications / Society for Applied Spectroscopy | en_GB |
dc.rights | © The Author(s) 2020. Open access. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). | |
dc.subject | Biomechanics | |
dc.subject | Biopolymers | |
dc.subject | Brillouin microscopy | |
dc.subject | Raman scattering | |
dc.subject | Vibrational spectroscopy | |
dc.title | Predicting the Refractive Index of Tissue Models Using Light Scattering Spectroscopy | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-12-08T09:02:47Z | |
dc.identifier.issn | 0003-7028 | |
dc.description | This is the final version. Available on open access from SAGE Publications via the DOI in this record | en_GB |
dc.description | Data availability: All data needed to evaluate the conclusions in the paper are present herein. Additional data related to this paper may be requested from the corresponding author. | en_GB |
dc.identifier.journal | Applied Spectroscopy | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-12-07 | |
exeter.funder | ::Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
exeter.funder | ::Cancer Research UK | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-12-07 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-12-07T18:29:44Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-12-18T15:36:11Z | |
refterms.panel | B | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Open access. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).