The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood
| dc.contributor.author | Schnurr, TM | |
| dc.contributor.author | Morgen, CS | |
| dc.contributor.author | Borisevich, D | |
| dc.contributor.author | Beaumont, RN | |
| dc.contributor.author | Engelbrechtsen, L | |
| dc.contributor.author | Ängquist, L | |
| dc.contributor.author | Have, CT | |
| dc.contributor.author | Freathy, RM | |
| dc.contributor.author | Smith, GD | |
| dc.contributor.author | Nohr, EA | |
| dc.contributor.author | Hansen, T | |
| dc.contributor.author | Sørensen, TIA | |
| dc.date.accessioned | 2021-02-17T11:18:23Z | |
| dc.date.issued | 2020-03-16 | |
| dc.description.abstract | Overweight in children is strongly associated with parental body mass index (BMI) and overweight. We assessed parental transmitted and non-transmitted genetic contributions to overweight in children from the Danish National Birth Cohort by constructing genetic risk scores (GRSs) from 941 common genetic variants associated with adult BMI and estimating associations of transmitted maternal/paternal and non-transmitted maternal GRS with child overweight. Maternal and paternal BMI (standard deviation (SD) units) had a strong association with childhood overweight [Odds ratio (OR): 2.01 (95% confidence interval (CI) 1.74; 2.34) and 1.64 (95% CI 1.43; 1.89)]. Maternal and paternal transmitted GRSs (SD-units) increased odds for child overweight equally [OR: 1.30 (95% CI 1.16; 1.46) and 1.30 (95% CI 1.16; 1.47)]. However, both the parental phenotypic and the GRS associations may depend on maternal BMI, being weaker among mothers with overweight. Maternal non-transmitted GRS was not associated with child overweight [OR 0.98 (95% CI 0.88; 1.10)] suggesting no specific influence of maternal adiposity as such. In conclusion, parental transmitted GRSs, based on adult BMI, contribute to child overweight, but in overweight mothers other genetic and environmental factors may play a greater role. | en_GB |
| dc.description.sponsorship | Wellcome Trust | en_GB |
| dc.description.sponsorship | Royal Society | en_GB |
| dc.identifier.citation | Vol. 10, article 4806 | en_GB |
| dc.identifier.doi | 10.1038/s41598-020-61719-3 | |
| dc.identifier.grantnumber | WT104150 | en_GB |
| dc.identifier.uri | http://hdl.handle.net/10871/124774 | |
| dc.language.iso | en | en_GB |
| dc.publisher | Nature Research | en_GB |
| dc.rights | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_GB |
| dc.title | The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood | en_GB |
| dc.type | Article | en_GB |
| dc.date.available | 2021-02-17T11:18:23Z | |
| dc.identifier.issn | 2045-2322 | |
| dc.description | This is the final version. Available from Nature Research via the DOI in this record. | en_GB |
| dc.description | Relevant data for the present study are within the paper and its Supporting Information fles. Access to additional individual data underlying the fndings may be approved with some restrictions. Data is available from the Danish National Birth Cohort and can be requested through the steering committee of the study who can be contacted under dnbc-research@ssi.dk. More information regarding access to data can be found on the Danish National Birth Cohort website http://www.dnbc.dk/access-to-dnbc-data. | en_GB |
| dc.identifier.journal | Scientific Reports | en_GB |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
| dcterms.dateAccepted | 2020-02-24 | |
| exeter.funder | ::Wellcome Trust | en_GB |
| rioxxterms.version | VoR | en_GB |
| rioxxterms.licenseref.startdate | 2020-03-16 | |
| rioxxterms.type | Journal Article/Review | en_GB |
| refterms.dateFCD | 2021-02-17T11:05:27Z | |
| refterms.versionFCD | VoR | |
| refterms.dateFOA | 2021-02-17T11:18:30Z | |
| refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.