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dc.contributor.authorHartley, S
dc.contributor.authorSmith, RDJ
dc.contributor.authorKokotovich, A
dc.contributor.authorOpesen, C
dc.contributor.authorHabtewold, T
dc.contributor.authorLedingham, K
dc.contributor.authorRaymond, B
dc.contributor.authorRwabukwali, CB
dc.date.accessioned2021-05-21T14:36:12Z
dc.date.issued2021-03-16
dc.description.abstractBackground: The African Union’s High-Level Panel on Emerging Technologies identified gene drive mosquitoes as a priority technology for malaria elimination. The first field trials are expected in 5–10 years in Uganda, Mali or Burkina Faso. In preparation, regional and international actors are developing risk governance guidelines which will delineate the framework for identifying and evaluating risks. Scientists and bioethicists have called for African stakeholder involvement in these developments, arguing the knowledge and perspectives of those people living in malaria-afflicted countries is currently missing. However, few African stakeholders have been involved to date, leaving a knowledge gap about the local social-cultural as well as ecological context in which gene drive mosquitoes will be tested and deployed. This study investigates and analyses Ugandan stakeholders’ hopes and concerns about gene drive mosquitoes for malaria control and explores the new directions needed for risk governance. Methods: This qualitative study draws on 19 in-depth semi-structured interviews with Ugandan stakeholders in 2019. It explores their hopes for the technology and the risks they believed pertinent. Coding began at a workshop and continued through thematic analysis. Results: Participants’ hopes and concerns for gene drive mosquitoes to address malaria fell into three themes: (1) ability of gene drive mosquitoes to prevent malaria infection; (2) impacts of gene drive testing and deployment; and, (3) governance. Stakeholder hopes fell almost exclusively into the first theme while concerns were spread across all three. The study demonstrates that local stakeholders are able and willing to contribute relevant and important knowledge to the development of risk frameworks. Conclusions: International processes can provide high-level guidelines, but risk decision-making must be grounded in the local context if it is to be robust, meaningful and legitimate. Decisions about whether or not to release gene drive mosquitoes as part of a malaria control programme will need to consider the assessment of both the risks and the benefits of gene drive mosquitoes within a particular social, political, ecological, and technological context. Just as with risks, benefits—and importantly, the conditions that are necessary to realize them—must be identified and debated in Uganda and its neighbouring countries.en_GB
dc.description.sponsorshipBritish Academyen_GB
dc.identifier.citationVol. 20, article 149en_GB
dc.identifier.doi10.1186/s12936-021-03682-6
dc.identifier.grantnumberKF2\100179en_GB
dc.identifier.grantnumberKF400306en_GB
dc.identifier.urihttp://hdl.handle.net/10871/125776
dc.language.isoenen_GB
dc.publisherBMCen_GB
dc.relation.urlhttps://ukdataservice.ac.uk/
dc.rights© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_GB
dc.subjectMalaria controlen_GB
dc.subjectGene drive mosquitoesen_GB
dc.subjectUgandaen_GB
dc.subjectStakeholdersen_GB
dc.subjectRisk governanceen_GB
dc.subjectRisk assessmenten_GB
dc.subjectTarget Malariaen_GB
dc.titleUgandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governanceen_GB
dc.typeArticleen_GB
dc.date.available2021-05-21T14:36:12Z
dc.identifier.issn1475-2875
dc.descriptionThis is the final version. Available on open access from BMC via the DOI in this record. en_GB
dc.descriptionAvailability of data and materials: The datasets generated during and/or analyzed during the current study are available in the UK DATA SERVICE repository, https://ukdataservice.ac.uk/. The datasets during and/or analyzed during the current study are also available from the corresponding author on reasonable request.en_GB
dc.identifier.journalMalaria Journalen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2021-03-03
exeter.funder::British Academyen_GB
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2021-03-16
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-05-21T14:29:58Z
refterms.versionFCDVoR
refterms.dateFOA2021-05-21T14:36:30Z
refterms.panelCen_GB


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© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and
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permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Except where otherwise noted, this item's licence is described as © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.