Phenylalanine hydroxylase contributes to serotonin synthesis in mice
dc.contributor.author | Mordhorst, A | |
dc.contributor.author | Dhandapani, P | |
dc.contributor.author | Matthes, S | |
dc.contributor.author | Mosienko, V | |
dc.contributor.author | Rothe, M | |
dc.contributor.author | Todiras, M | |
dc.contributor.author | Self, J | |
dc.contributor.author | Schunck, W | |
dc.contributor.author | Schütz, A | |
dc.contributor.author | Bader, M | |
dc.contributor.author | Alenina, N | |
dc.date.accessioned | 2021-05-28T13:21:54Z | |
dc.date.issued | 2021-05-16 | |
dc.description.abstract | Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate-limiting step of its synthesis. In most vertebrates, two enzymes have been described to catalyze this step, tryptophan hydroxylase (TPH) 1 and 2, with expression localized to peripheral and neuronal cells, respectively. However, animals lacking both TPH isoforms still exhibit about 10% of normal serotonin levels in the blood demanding an additional source of the monoamine. In this study, we provide evidence by the gain and loss of function approaches in in vitro and in vivo systems, including stable-isotope tracing in mice, that phenylalanine hydroxylase (PAH) is a third TPH in mammals. PAH contributes to serotonin levels in the blood, and may be important as a local source of serotonin in organs in which no other TPHs are expressed, such as liver and kidney. | en_GB |
dc.description.sponsorship | Saint Petersburg State University (SPbU) | en_GB |
dc.description.sponsorship | Bundesministerium für Bildung und Forschung (BMBF) | en_GB |
dc.description.sponsorship | Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) | en_GB |
dc.description.sponsorship | Volkswagen Foundation (VolkswagenStiftung) | en_GB |
dc.identifier.citation | Vol. 35 (6), article e21648 | en_GB |
dc.identifier.doi | 10.1096/fj.202100366r | |
dc.identifier.grantnumber | 51143531 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/125865 | |
dc.language.iso | en | en_GB |
dc.publisher | Federation of American Society of Experimental Biology (FASEB) | en_GB |
dc.rights | © 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_GB |
dc.subject | phenylalanine hydroxylase | en_GB |
dc.subject | serotonin | en_GB |
dc.subject | tryptophan hydroxylase | en_GB |
dc.title | Phenylalanine hydroxylase contributes to serotonin synthesis in mice | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-05-28T13:21:54Z | |
dc.identifier.issn | 0892-6638 | |
dc.description | This is the final version. Available from the Federation of American Society of Experimental Biology via the DOI in this record. | en_GB |
dc.identifier.journal | FASEB Journal | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2021-04-21 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-04-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-05-28T13:15:18Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-05-28T13:22:06Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.