In vivo Measurement of Intraosseous Vascular Haemodynamic Markers in Human Bone Tissue Utilising Near Infrared Spectroscopy
dc.contributor.author | Meertens, R | |
dc.contributor.author | Knapp, KM | |
dc.contributor.author | Strain, WD | |
dc.contributor.author | Casanova, F | |
dc.contributor.author | Ball, S | |
dc.contributor.author | Fulford, J | |
dc.contributor.author | Thorn, C | |
dc.date.accessioned | 2021-09-27T15:32:21Z | |
dc.date.issued | 2021-09-24 | |
dc.description.abstract | Objective: Poor vascular health is associated with reduced bone strength and increased risk of fragility fracture. However, direct measurement of intraosseous vascular health is difficult due to the density and mineral content of bone. We investigated the feasibility of using a commercially available continuous wave near infrared spectroscopy (NIRS) system for the investigation of vascular haemodynamics in human bone in vivo. Approach: An arterial occlusion (AO) protocol was developed for obtaining haemodynamic measurements of the proximal tibia and lateral calf, including assessment of the protocol’s intra operator reproducibility. For 36 participants, intraosseous haemodynamics derived by NIRS were compared to alternative tests of bone health based on dual x-ray absorptiometry (DXA) testing and MRI. Main Results: Near infrared spectroscopy markers of haemodynamics of the proximal tibia demonstrated acceptable reproducibility, comparable with reproducibility assessments of alternative modalities measuring intraosseous haemodynamics, and the use of NIRS for measuring muscle. Novel associations have been demonstrated between haemodynamic markers of bone measured with NIRS and body composition and bone mineral density (BMD) measurements obtained with both DXA and MRI. Significance: Near infrared spectroscopy provides inexpensive, non-invasive, safe, and real time data on changes in oxygenated and deoxygenated haemoglobin concentration in bone at the proximal tibia. This study has demonstrated the potential for NIRS to contribute to research investigating the pathophysiological role of vascular dysfunction within bone tissue, but also the limitations and need for further development of NIRS technology. | en_GB |
dc.description.sponsorship | College of Radiographers | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 12, article 738239 | en_GB |
dc.identifier.doi | 10.3389/fphys.2021.738239 | |
dc.identifier.grantnumber | 003 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/127252 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2021 Meertens, Knapp, Strain, Casanova, Ball, Fulford and Thorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | near infrared spectroscopy | en_GB |
dc.subject | bone | en_GB |
dc.subject | tibia | en_GB |
dc.subject | haemodynamic analysis | en_GB |
dc.subject | vascular physiology | en_GB |
dc.title | In vivo Measurement of Intraosseous Vascular Haemodynamic Markers in Human Bone Tissue Utilising Near Infrared Spectroscopy | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-09-27T15:32:21Z | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.description | Data Availability Statement: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. | en_GB |
dc.identifier.eissn | 1664-042X | |
dc.identifier.journal | Frontiers in Physiology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-08-25 | |
exeter.funder | ::The Royal College of Radiologists | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-09-24 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-09-27T15:28:59Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-09-27T15:34:35Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2021 Meertens, Knapp, Strain, Casanova, Ball, Fulford and Thorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.