| dc.description.abstract | Introduction
The aim of this study is to review analytical methods that enable the incorporation of equity concerns within
economic evaluation.
Methods
A systematic search of PubMed, Embase and EconLit was undertaken from database inception to February
2021. The search was designed to identify methodological approaches that are currently employed to evaluate
health-related equity impacts in economic evaluation studies of health care interventions. Studies were eligible if
they described or elaborated on a formal quantitative method used to integrate equity concerns within economic
evaluation studies. Cost-utility, cost-effectiveness, cost-benefit, cost-minimisation and, cost-consequence
analyses, as well as health technology appraisal and budget impact analysis, alongside any relevant literature
reviews, were included. For each of the identified methods, summaries of the scope of equity considerations
covered, the methods employed and their key attributes, data requirements, outcomes, and strengths and
weaknesses were provided. A traffic light assessment of the practical suitability of each method was undertaken,
alongside a worked example, applying the different methods to evaluate the same decision problem. Finally, the
review summarises the typical trade-offs arising in cost-effectiveness analyses and discusses the extent to which
the evaluation methods are able to capture these.
Results
In total, 68 studies were included in the review and methods could broadly be grouped into equity-based
weighting (EBW) methods, extended cost-effectiveness analysis (ECEA), distributional cost-effectiveness
analysis (DCEA), multi-criteria decision analysis (MCDA), and mathematical programming (MP). EBW and
MP methods enable equity consideration through adjustment to incremental cost-effectiveness ratios, whilst
equity considerations are represented through financial risk protection (FRP) outcomes in ECEA, social welfare
functions (SWFs) in DCEA, and scoring/ranking systems in MCDA. The review identified potential concerns
for EBW methods and MCDA with respect to data availability, and EBW methods and MP with respect to
explicitly measuring changes in inequality. The only potential concern for ECEA relates to the use of FRP
metrics which may not be relevant for all healthcare systems. In contrast, DCEA observed no significant
concerns but relies on the use of SWFs which may be unfamiliar to some audiences and requires societal
preference elicitation. Consideration of typical cost-effectiveness and equity-related trade-offs highlighted the
flexibility of most methods with respect to their ability to capture such trade-offs. Notable exceptions were
trade-offs between quality of life and length of life, for which we find DCEA and ECEA unsuitable, and the
assessment of lost opportunity costs, for which we find only DCEA and MP to be suitable. The worked example
demonstrated that each method is designed with fundamentally different analytical objectives in mind.
Conclusions
The review emphasises that, not only are some approaches better suited to particular decision problems than
others, but also that methods are subject to different practical requirements and that significantly different
conclusions can be observed depending on the choice of method and the assumptions made. Further, to fully
operationalise these frameworks, there remains a need to develop consensus over the motivation for equity
assessment, which should necessarily be informed with stakeholder involvement. Future research of this topic
should be a priority, particularly within the context of equity evaluation in health care policy decisions. | en_GB |
