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dc.contributor.authorLong, KC
dc.contributor.authorAlphey, L
dc.contributor.authorAnnas, GJ
dc.contributor.authorBloss, CS
dc.contributor.authorCampbell, KJ
dc.contributor.authorChamper, J
dc.contributor.authorChen, C-H
dc.contributor.authorChoudhary, A
dc.contributor.authorChurch, GM
dc.contributor.authorCollins, JP
dc.contributor.authorCooper, KL
dc.contributor.authorDelborne, JA
dc.contributor.authorEdwards, OR
dc.contributor.authorEmerson, CI
dc.contributor.authorEsvelt, K
dc.contributor.authorEvans, SW
dc.contributor.authorFriedman, RM
dc.contributor.authorGantz, VM
dc.contributor.authorGould, F
dc.contributor.authorHartley, S
dc.contributor.authorHeitman, E
dc.contributor.authorHemingway, J
dc.contributor.authorKanuka, H
dc.contributor.authorKuzma, J
dc.contributor.authorLavery, JV
dc.contributor.authorLee, Y
dc.contributor.authorLorenzen, M
dc.contributor.authorLunshof, JE
dc.contributor.authorMarshall, JM
dc.contributor.authorMesser, PW
dc.contributor.authorMontell, C
dc.contributor.authorOye, KA
dc.contributor.authorPalmer, MJ
dc.contributor.authorPapathanos, PA
dc.contributor.authorParadkar, PN
dc.contributor.authorPiaggio, AJ
dc.contributor.authorRasgon, JL
dc.contributor.authorRašić, G
dc.contributor.authorRudenko, L
dc.contributor.authorSaah, JR
dc.contributor.authorScott, MJ
dc.contributor.authorSutton, JT
dc.contributor.authorVorsino, AE
dc.contributor.authorAkbari, OS
dc.date.accessioned2022-02-25T09:36:59Z
dc.date.issued2020-12-18
dc.date.updated2022-02-11T19:51:02Z
dc.description.abstractGene drive organisms (GDOs), whose genomes have been genetically engineered to spread a desired allele through a population, have the potential to transform the way societies address a wide range of daunting public health and environmental challenges. The development, testing, and release of GDOs, however, are complex and often controversial. A key challenge is to clarify the appropriate roles of developers and others actively engaged in work with GDOs in decision-making processes, and, in particular, how to establish partnerships with relevant authorities and other stakeholders. Several members of the gene drive community previously proposed safeguards for laboratory experiments with GDOs (1) that, in the absence of national or international guidelines, were considered essential for responsible laboratory work to proceed. Now, with GDO development advancing in laboratories (2–5), we envision similar safeguards for the potential next step: ecologically and/or genetically confined field trials to further assess the performance of GDOs. A GDO's propensity to spread necessitates well-developed criteria for field trials to assess its potential impacts (6). We, as a multidisciplinary group of GDO developers, ecologists, conservation biologists, and experts in social science, ethics, and policy, outline commitments below that we deem critical for responsible conduct of a field trial and to ensure that these technologies, if they are introduced, serve the public interest.en_GB
dc.description.sponsorshipBritish Academyen_GB
dc.description.sponsorshipBritish Academyen_GB
dc.format.extent1417-1419
dc.format.mediumPrint
dc.identifier.citationVol. 370, No. 6523, pp. 1417-1419en_GB
dc.identifier.doihttps://doi.org/10.1126/science.abd1908
dc.identifier.grantnumberKF2\100179en_GB
dc.identifier.grantnumberKF400306en_GB
dc.identifier.urihttp://hdl.handle.net/10871/128883
dc.identifierORCID: 0000-0002-4849-5685 (Hartley, Sarah)
dc.language.isoenen_GB
dc.publisherAmerican Association for the Advancement of Scienceen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/33335055en_GB
dc.rightsCopyright © 2020, American Association for the Advancement of Scienceen_GB
dc.subjectGene Driveen_GB
dc.subjectField Trialen_GB
dc.subjectResponsible Conduct of Researchen_GB
dc.subjectBiosafetyen_GB
dc.titleCore commitments for field trials of gene drive organismsen_GB
dc.typeArticleen_GB
dc.date.available2022-02-25T09:36:59Z
dc.identifier.issn0036-8075
exeter.place-of-publicationUnited States
dc.descriptionThis is the author accepted manuscript. The final version is available from the American Association for the Advancement of Science via the DOI in this record en_GB
dc.identifier.eissn1095-9203
dc.identifier.journalScienceen_GB
dc.relation.ispartofScience, 370(6523)
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2020-12-18
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-02-11T19:51:06Z
refterms.versionFCDAM
refterms.dateFOA2022-02-25T09:39:35Z
refterms.panelCen_GB


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