Radical Scavenging Could Answer the Challenge Posed by Electron-Electron Dipolar Interactions in the Cryptochrome Compass Model
dc.contributor.author | Babcock, NS | |
dc.contributor.author | Kattnig, DR | |
dc.date.accessioned | 2022-03-15T14:50:46Z | |
dc.date.issued | 2021-10-05 | |
dc.date.updated | 2022-03-15T14:30:37Z | |
dc.description.abstract | Many birds are endowed with a visual magnetic sense that may exploit magnetosensitive radical recombination processes in the protein cryptochrome. In this widely accepted but unproven model, geomagnetic sensitivity is suggested to arise from variations in the recombination rate of a pair of radicals, whose unpaired electron spins undergo coherent singlet-triplet interconversion in the geomagnetic field by coupling to nuclear spins via hyperfine interactions. However, simulations of this conventional radical pair mechanism (RPM) predicted only tiny magnetosensitivities for realistic conditions because the RPM's directional sensitivity is strongly suppressed by the intrinsic electron-electron dipolar (EED) interactions, casting doubt on its viability as a magnetic sensor. We show how this RPM-suppression problem is overcome in a three-radical system in which a third "scavenger" radical reacts with one member of the primary pair. We use this finding to predict substantial magnetic field effects that exceed those of the RPM in the presence of EED interactions in animal cryptochromes. | en_GB |
dc.description.sponsorship | UK Defence Science and Technology Laboratory | en_GB |
dc.description.sponsorship | Office of Naval Research (ONR) | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.format.extent | 2033-2046 | |
dc.identifier.citation | Vol. 1 (11), pp. 2033-2046 | en_GB |
dc.identifier.doi | https://doi.org/10.1021/jacsau.1c00332 | |
dc.identifier.grantnumber | DSTLX-1000139168 | en_GB |
dc.identifier.grantnumber | N62909-21-1-2018 | en_GB |
dc.identifier.grantnumber | EP/R021058/1 | en_GB |
dc.identifier.grantnumber | EP/V047175/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/129058 | |
dc.identifier | ORCID: 0000-0003-4236-2627 (Kattnig, Daniel R) | |
dc.language.iso | en | en_GB |
dc.publisher | American Chemical Society (ACS) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/34841416 | en_GB |
dc.rights | © 2021 The Authors. Published by American Chemical Society. Open access under a Creative Commons licence: https://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | magnetoreception | en_GB |
dc.subject | radical pair mechanism | en_GB |
dc.subject | electron−electron dipolar coupling | en_GB |
dc.subject | three-radical effects | en_GB |
dc.subject | cryptochrome | en_GB |
dc.title | Radical Scavenging Could Answer the Challenge Posed by Electron-Electron Dipolar Interactions in the Cryptochrome Compass Model | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-03-15T14:50:46Z | |
dc.identifier.issn | 2691-3704 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available on open access from the American Chemical Society via the DOI in this record | en_GB |
dc.description | Data availability: The numerical data that this study has generated are available from the authors upon request. | en_GB |
dc.identifier.eissn | 2691-3704 | |
dc.identifier.journal | JACS Au | en_GB |
dc.relation.ispartof | JACS Au, 1(11) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-11-22 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-03-15T14:46:52Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-03-15T14:51:01Z | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2021-10-05 |
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Except where otherwise noted, this item's licence is described as © 2021 The Authors. Published by American Chemical Society. Open access under a Creative Commons licence: https://creativecommons.org/licenses/by/4.0/