Clinical and Biomedical Sciences: Recent submissions
Now showing items 16-20 of 330
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Hypoglycaemic stimulation of macrophage cytokine release is suppressed by AMP-activated protein kinase activation
(Wiley, 2024)Aims/hypothesis: Acute hypoglycaemia promotes pro-inflammatory cytokine production, increasing risk for cardiovascular events in diabetes. AMP-activated protein kinase (AMPK) is regulated by and influences production of ... -
Population bursts in a modular neural network as a mechanism for synchronized activity in KNDy neurons
(Public Library of Science (PLoS), 31 July 2024)The pulsatile activity of gonadotropin-releasing hormone neurons (GnRH neurons) is a key factor in the regulation of reproductive hormones. This pulsatility is orchestrated by a network of neurons that release the ... -
Reusable glassware for routine cell culture—a sterile, sustainable and affordable alternative to single-use plastics
(Frontiers Media, 25 September 2024)Cell culture is a cornerstone of in vitro biological research. Whilst glassware was once commonplace in tissue culture facilities, in recent decades laboratories have moved towards a heavy reliance on single use plastics ... -
The potential roles of reactive nitrogen species in host defence against pathogens and in human health and autoimmune inflammatory diseases
(University of Exeter CBS, 7 October 2024)The human immune system defends the body against infectious pathogens such as bacteria and viruses. In humans, oral bacteria reduce dietary nitrate (NO3ˉ) to nitrite (NO2ˉ). NO2ˉ is swallowed into the acidic stomach ... -
Comparison of Reporting Quality in National Cystic Fibrosis Patient Registries: Implications for Identifying Use of Novel CFTR Modulators
(Springer, 27 September 2024)Introduction Advances in development of cystic fibrosis transmembrane conductance regulator modulator (CFTRm) therapies mean that now people who are heterozygous (instead of having to be homozygous) for the common F508del ...