Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis
dc.contributor.author | Khan, F | |
dc.contributor.author | Gonçalves, I | |
dc.contributor.author | Shore, AC | |
dc.contributor.author | Natali, A | |
dc.contributor.author | Palombo, C | |
dc.contributor.author | Colhoun, HM | |
dc.contributor.author | Östling, G | |
dc.contributor.author | Casanova, F | |
dc.contributor.author | Kennbäck, C | |
dc.contributor.author | Aizawa, K | |
dc.contributor.author | Persson, M | |
dc.contributor.author | Gooding, KM | |
dc.contributor.author | Strain, D | |
dc.contributor.author | Looker, H | |
dc.contributor.author | Dove, F | |
dc.contributor.author | Belch, J | |
dc.contributor.author | Pinnola, S | |
dc.contributor.author | Venturi, E | |
dc.contributor.author | Kozakova, M | |
dc.contributor.author | Nilsson, J | |
dc.date.accessioned | 2022-09-15T13:07:33Z | |
dc.date.issued | 2022-07-19 | |
dc.date.updated | 2022-09-15T11:18:41Z | |
dc.description.abstract | The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] -0.14 [-0.06 to -0.02] p = 0.001, 0.15 [0.02-0.07] p = 0.001, and 0.20 [0.03-0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15-0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF. | en_GB |
dc.description.sponsorship | Innovative Medicines Initiative | en_GB |
dc.description.sponsorship | Swedish Heart-Lung Foundation | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.format.extent | 100676- | |
dc.format.medium | ||
dc.identifier.citation | Vol. 3(7), article 100676 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.xcrm.2022.100676 | |
dc.identifier.grantnumber | IMI-2008/115006 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/130849 | |
dc.identifier | ORCID: 0000-0003-3039-308X (Shore, Angela C) | |
dc.identifier | ORCID: 0000-0003-0275-4765 (Casanova, Francesco) | |
dc.identifier | ScopusID: 18436139700 | 56592223400 (Casanova, Francesco) | |
dc.identifier | ORCID: 0000-0002-0025-2115 (Aizawa, Kunihiko) | |
dc.identifier | ORCID: 0000-0002-1825-9825 (Gooding, Kim M) | |
dc.identifier | ORCID: 0000-0002-6826-418X (Strain, David) | |
dc.identifier | ScopusID: 56602727900 | 9244119500 (Strain, David) | |
dc.identifier | ResearcherID: Y-9858-2019 (Strain, David) | |
dc.language.iso | en | en_GB |
dc.publisher | Cell Press | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35858591 | en_GB |
dc.rights | Crown Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.subject | atherosclerosis | en_GB |
dc.subject | biomarkers | en_GB |
dc.subject | carotid ultrasound | en_GB |
dc.subject | intima-media thickness | en_GB |
dc.subject | risk factors | en_GB |
dc.subject | type 2 diabetes | en_GB |
dc.subject | Atherosclerosis | en_GB |
dc.subject | Biomarkers | en_GB |
dc.subject | Carotid Artery Diseases | en_GB |
dc.subject | Carotid Intima-Media Thickness | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Plaque, Atherosclerotic | en_GB |
dc.subject | Risk Factors | en_GB |
dc.subject | Tomography, X-Ray Computed | en_GB |
dc.title | Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-09-15T13:07:33Z | |
dc.identifier.issn | 2666-3791 | |
exeter.article-number | 100676 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available on open access from Cell Press via the DOI in this record | en_GB |
dc.description | Data and code availability: • All data reported in this paper will be shared by the lead contact upon request. • This paper does not report original code. • Any additional information required to reanalyze the data reported in this work paper is available from the lead contact upon request. | en_GB |
dc.identifier.eissn | 2666-3791 | |
dc.identifier.journal | Cell Reports Medicine | en_GB |
dc.relation.ispartof | Cell Rep Med, 3(7) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2022-06-10 | |
dc.rights.license | CC BY-NC-ND | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-07-19 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-09-15T13:05:03Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-09-15T13:07:43Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as Crown Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).