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Quantitative approaches in clinical reproductive endocrinology

dc.contributor.authorVoliotis, M
dc.contributor.authorHanassab, S
dc.contributor.authorAbbara, A
dc.contributor.authorHeinis, T
dc.contributor.authorDhillo, WS
dc.contributor.authorTsaneva-Atanasova, K
dc.date.accessioned2022-10-13T10:56:42Z
dc.date.issued2022-10-06
dc.date.updated2022-10-13T10:18:33Z
dc.description.abstractUnderstanding the human hypothalamus-pituitary-gonadal (HPG) axis presents a major challenge for medical science. Dysregulation of the HPG axis is linked to infertility and a thorough understanding of its dynamic behaviour is necessary to both aid diagnosis and to identify the most appropriate hormonal interventions. Here, we review how quantitative models are being used in the context of clinical reproductive endocrinology to: 1. analyse the secretory patterns of reproductive hormones; 2. evaluate the effect of drugs in fertility treatment; 3. aid in the personalization of assisted reproductive technology (ART). In this review, we demonstrate that quantitative models are indispensable tools enabling us to describe the complex dynamic behaviour of the reproductive axis, refine treatment of fertility disorders, and predict clinical intervention outcomes.en_GB
dc.description.sponsorshipEngineering and Physical Sciences Research Council (EPSRC)en_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.description.sponsorshipNational Institute for Health Research (NIHR)en_GB
dc.description.sponsorshipUKRIen_GB
dc.format.extent100421-
dc.identifier.citationArticle 100421en_GB
dc.identifier.doihttps://doi.org/10.1016/j.coemr.2022.100421
dc.identifier.grantnumberEP/T017856/1en_GB
dc.identifier.grantnumberEP/N014391/1en_GB
dc.identifier.grantnumberBB/S000550/1en_GB
dc.identifier.grantnumberBB/S001255/1en_GB
dc.identifier.grantnumberCS-2018-18-ST2-002en_GB
dc.identifier.grantnumberP/S023283/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/131250
dc.identifierORCID: 0000-0001-6488-7198 (Voliotis, Margaritis)
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rights© 2022 The Author(s). Published by Elsevier Ltd. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/en_GB
dc.titleQuantitative approaches in clinical reproductive endocrinologyen_GB
dc.typeArticleen_GB
dc.date.available2022-10-13T10:56:42Z
dc.identifier.issn2451-9650
exeter.article-number100421
dc.descriptionThis is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this recorden_GB
dc.descriptionData availability: No data was used for the research described in the article.en_GB
dc.identifier.journalCurrent Opinion in Endocrine and Metabolic Researchen_GB
dc.relation.ispartofCurrent Opinion in Endocrine and Metabolic Research
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2022-09-27
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2022-10-06
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2022-10-13T10:50:11Z
refterms.versionFCDAM
refterms.dateFOA2022-10-13T10:56:56Z
refterms.panelBen_GB


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© 2022 The Author(s). Published by Elsevier Ltd. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © 2022 The Author(s). Published by Elsevier Ltd. Open access under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/