Materials and methods for droplet microfluidic device fabrication.
dc.contributor.author | Elvira, KS | |
dc.contributor.author | Gielen, F | |
dc.contributor.author | Tsai, SSH | |
dc.contributor.author | Nightingale, AM | |
dc.date.accessioned | 2022-10-28T15:06:20Z | |
dc.date.issued | 2022-01-24 | |
dc.date.updated | 2022-10-28T14:43:50Z | |
dc.description.abstract | Since the first reports two decades ago, droplet-based systems have emerged as a compelling tool for microbiological and (bio)chemical science, with droplet flow providing multiple advantages over standard single-phase microfluidics such as removal of Taylor dispersion, enhanced mixing, isolation of droplet contents from surfaces, and the ability to contain and address individual cells or biomolecules. Typically, a droplet microfluidic device is designed to produce droplets with well-defined sizes and compositions that flow through the device without interacting with channel walls. Successful droplet flow is fundamentally dependent on the microfluidic device - not only its geometry but moreover how the channel surfaces interact with the fluids. Here we summarise the materials and fabrication techniques required to make microfluidic devices that deliver controlled uniform droplet flow, looking not just at physical fabrication methods, but moreover how to select and modify surfaces to yield the required surface/fluid interactions. We describe the various materials, surface modification techniques, and channel geometry approaches that can be used, and give examples of the decision process when determining which material or method to use by describing the design process for five different devices with applications ranging from field-deployable chemical analysers to water-in-water droplet creation. Finally we consider how droplet microfluidic device fabrication is changing and will change in the future, and what challenges remain to be addressed in the field. | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council | en_GB |
dc.description.sponsorship | European Union's Horizon 2020 | en_GB |
dc.description.sponsorship | Government of Canada's Natural Sciences and Engineering Research Council (NSERC) | en_GB |
dc.description.sponsorship | Natural Environment Research Council | en_GB |
dc.description.sponsorship | Natural Environment Research Council | en_GB |
dc.description.sponsorship | Canada Research Chairs program | en_GB |
dc.description.sponsorship | Michael Smith Foundation for Health Research | en_GB |
dc.description.sponsorship | Pacific Alzheimer Research Foundation | en_GB |
dc.format.extent | 859-875 | |
dc.format.medium | Electronic | |
dc.identifier.citation | Vol. 22, No. 5, pp. 859-875 | en_GB |
dc.identifier.doi | https://doi.org/10.1039/d1lc00836f | |
dc.identifier.grantnumber | BB/T011777/ 1 | en_GB |
dc.identifier.grantnumber | 101000560 | en_GB |
dc.identifier.grantnumber | RGPIN-2019-04618 | en_GB |
dc.identifier.grantnumber | NE/R013578/1 | en_GB |
dc.identifier.grantnumber | NE/T010584/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/131487 | |
dc.identifier | ORCID: 0000-0003-0604-7224 (Gielen, Fabrice) | |
dc.language.iso | en | en_GB |
dc.publisher | Royal Society of Chemistry | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35170611 | en_GB |
dc.rights | © The Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence | en_GB |
dc.subject | Lab-On-A-Chip Devices | en_GB |
dc.subject | Microfluidic Analytical Techniques | en_GB |
dc.subject | Microfluidics | en_GB |
dc.subject | Water | en_GB |
dc.title | Materials and methods for droplet microfluidic device fabrication. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-10-28T15:06:20Z | |
dc.identifier.issn | 1473-0197 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available from the Royal Society of Chemistry via the DOI in this record. | en_GB |
dc.identifier.eissn | 1473-0189 | |
dc.identifier.journal | Lab on a Chip | en_GB |
dc.relation.ispartof | Lab Chip, 22(5) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | en_GB |
dcterms.dateAccepted | 2022-01-21 | |
dc.rights.license | CC BY-NC | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-01-24 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-10-28T14:58:36Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-10-28T15:06:26Z | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2022-01-24 |
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