Biophysical models of early mammalian embryogenesis

Abstract

Embryo development is a critical and fascinating stage in the life cycle of many organisms. Despite decades of research, the earliest stages of mammalian embryogenesis are still poorly understood, caused by a scarcity of high-resolution spatial and temporal data, the use of only a few model organisms, and a paucity of truly multidisciplinary approaches that combine biological research with biophysical modelling and computational simulation. Here, we explain the theoretical frameworks and biophysical processes that are best suited to modelling the early mammalian embryo, review a comprehensive list of previous models, and discuss the most promising avenues for future work.