Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis.
dc.contributor.author | Ramsay, J | |
dc.contributor.author | Kattnig, DR | |
dc.date.accessioned | 2022-12-02T13:30:24Z | |
dc.date.issued | 2022-09-15 | |
dc.date.updated | 2022-12-02T12:46:46Z | |
dc.description.abstract | Adult hippocampal neurogenesis and hippocampus-dependent cognition in mice have been found to be adversely affected by hypomagnetic field exposure. The effect concurred with a reduction of reactive oxygen species in the absence of the geomagnetic field. A recent theoretical study suggests a mechanistic interpretation of this phenomenon in the framework of the Radical Pair Mechanism. According to this model, a flavin-superoxide radical pair, born in the singlet spin configuration, undergoes magnetic field-dependent spin dynamics such that the pair's recombination is enhanced as the applied magnetic field is reduced. This model has two ostensible weaknesses: a) the assumption of a singlet initial state is irreconcilable with known reaction pathways generating such radical pairs, and b) the model neglects the swift spin relaxation of free superoxide, which abolishes any magnetic sensitivity in geomagnetic/hypomagnetic fields. We here suggest that a model based on a radical triad and the assumption of a secondary radical scavenging reaction can, in principle, explain the phenomenon without unnatural assumptions, thus providing a coherent explanation of hypomagnetic field effects in biology. | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council | en_GB |
dc.description.sponsorship | UK Defence Science and Technology Laboratory | en_GB |
dc.description.sponsorship | Office of Naval Research | en_GB |
dc.description.sponsorship | Leverhulme Trust | en_GB |
dc.format.extent | e1010519- | |
dc.format.medium | Electronic-eCollection | |
dc.identifier.citation | Vol. 18, No. 9, article e1010519 | en_GB |
dc.identifier.doi | https://doi.org/10.1371/journal.pcbi.1010519 | |
dc.identifier.grantnumber | EP/R021058/1 | en_GB |
dc.identifier.grantnumber | EP/V047175/1 | en_GB |
dc.identifier.grantnumber | DSTLX-474100013916 | en_GB |
dc.identifier.grantnumber | N62909-21-1-201 | en_GB |
dc.identifier.grantnumber | RPG-2020-26 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/131930 | |
dc.identifier | ORCID: 0000-0003-4236-2627 (Kattnig, Daniel R) | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/36108063 | en_GB |
dc.rights | © 2022 Ramsay, Kattnig. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Flavins | en_GB |
dc.subject | Magnetic Fields | en_GB |
dc.subject | Mice | en_GB |
dc.subject | Neurogenesis | en_GB |
dc.subject | Reactive Oxygen Species | en_GB |
dc.subject | Superoxides | en_GB |
dc.title | Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-12-02T13:30:24Z | |
dc.identifier.issn | 1553-734X | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available from Public Library of Science via the DOI in this record. | en_GB |
dc.description | Data Availability: All relevant data are within the manuscript and its Supporting information files. | en_GB |
dc.identifier.eissn | 1553-7358 | |
dc.identifier.journal | PLoS Computational Biology | en_GB |
dc.relation.ispartof | PLoS Comput Biol, 18(9) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2022-08-27 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-09-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-12-02T13:23:50Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-12-02T13:30:25Z | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2022-09-15 |
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