The phenotype of type 1 diabetes in sub-Saharan Africa
dc.contributor.author | Katte, JC | |
dc.contributor.author | McDonald, TJ | |
dc.contributor.author | Sobngwi, E | |
dc.contributor.author | Jones, AG | |
dc.date.accessioned | 2023-02-24T13:02:04Z | |
dc.date.issued | 2023-01-27 | |
dc.date.updated | 2023-02-24T12:20:56Z | |
dc.description.abstract | The phenotype of type 1 diabetes in Africa, especially sub-Saharan Africa, is poorly understood. Most previously conducted studies have suggested that type 1 diabetes may have a different phenotype from the classical form of the disease described in western literature. Making an accurate diagnosis of type 1 diabetes in Africa is challenging, given the predominance of atypical diabetes forms and limited resources. The peak age of onset of type 1 diabetes in sub-Saharan Africa seems to occur after 18-20 years. Multiple studies have reported lower rates of islet autoantibodies ranging from 20 to 60% amongst people with type 1 diabetes in African populations, lower than that reported in other populations. Some studies have reported much higher levels of retained endogenous insulin secretion than in type 1 diabetes elsewhere, with lower rates of type 1 diabetes genetic susceptibility and HLA haplotypes. The HLA DR3 appears to be the most predominant HLA haplotype amongst people with type 1 diabetes in sub-Saharan Africa than the HLA DR4 haplotype. Some type 1 diabetes studies in sub-Saharan Africa have been limited by small sample sizes and diverse methods employed. Robust studies close to diabetes onset are sparse. Large prospective studies with well-standardized methodologies in people at or close to diabetes diagnosis in different population groups will be paramount to provide further insight into the phenotype of type 1 diabetes in sub-Saharan Africa. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.format.extent | 1014626- | |
dc.format.medium | Electronic-eCollection | |
dc.identifier.citation | Vol. 11, article 1014626 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fpubh.2023.1014626 | |
dc.identifier.grantnumber | GHR-17/63/131 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/132537 | |
dc.identifier | ORCID: 0000-0003-3559-6660 (McDonald, Timothy J) | |
dc.identifier | ScopusID: 54393616700 (McDonald, Timothy J) | |
dc.identifier | ORCID: 0000-0002-0883-7599 (Jones, Angus G) | |
dc.identifier | ScopusID: 7407101887 (Jones, Angus G) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/36778553 | en_GB |
dc.rights | © 2023 Katte, McDonald, Sobngwi and Jones. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | C-peptide | en_GB |
dc.subject | beta-cell | en_GB |
dc.subject | characteristics | en_GB |
dc.subject | genetics | en_GB |
dc.subject | islet autoimmunity | en_GB |
dc.subject | phenotype [MeSH] | en_GB |
dc.subject | sub-Saharan Africa | en_GB |
dc.subject | type 1 diabetes | en_GB |
dc.title | The phenotype of type 1 diabetes in sub-Saharan Africa | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-02-24T13:02:04Z | |
dc.identifier.issn | 2296-2565 | |
exeter.place-of-publication | Switzerland | |
dc.description | This is the final version. Available from Frontiers Media via the DOI in this record. | en_GB |
dc.identifier.eissn | 2296-2565 | |
dc.identifier.journal | Frontiers in Public Health | en_GB |
dc.relation.ispartof | Front Public Health, 11 | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-01-10 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-01-27 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-02-24T12:59:42Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-02-24T13:02:09Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-01-27 |
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