Spatial distribution of heterogeneity as a modulator of collective dynamics in pancreatic beta-cell networks and beyond
dc.contributor.author | Galvis, D | |
dc.contributor.author | Hodson, DJ | |
dc.contributor.author | Wedgwood, KCA | |
dc.date.accessioned | 2023-03-27T09:56:08Z | |
dc.date.issued | 2023-03-24 | |
dc.date.updated | 2023-03-27T08:05:49Z | |
dc.description.abstract | We study the impact of spatial distribution of heterogeneity on collective dynamics in gap-junction coupled beta-cell networks comprised on cells from two populations that differ in their intrinsic excitability. Initially, these populations are uniformly and randomly distributed throughout the networks. We develop and apply an iterative algorithm for perturbing the arrangement of the network such that cells from the same population are increasingly likely to be adjacent to one another. We find that the global input strength, or network drive, necessary to transition the network from a state of quiescence to a state of synchronised and oscillatory activity decreases as network sortedness increases. Moreover, for weak coupling, we find that regimes of partial synchronisation and wave propagation arise, which depend both on network drive and network sortedness. We then demonstrate the utility of this algorithm for studying the distribution of heterogeneity in general networks, for which we use Watts–Strogatz networks as a case study. This work highlights the importance of heterogeneity in node dynamics in establishing collective rhythms in complex, excitable networks and has implications for a wide range of real-world systems that exhibit such heterogeneity. | en_GB |
dc.description.sponsorship | University of Birmingham Dynamic Investment Fund | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.description.sponsorship | UKRI | en_GB |
dc.description.sponsorship | European Union Horizon 2020 | en_GB |
dc.identifier.citation | Vol. 3, article 1170930 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fnetp.2023.1170930 | |
dc.identifier.grantnumber | EP/N014391/2 | en_GB |
dc.identifier.grantnumber | MR/N00275X/1 | en_GB |
dc.identifier.grantnumber | MR/S025618/1 | en_GB |
dc.identifier.grantnumber | 17/0005681 | en_GB |
dc.identifier.grantnumber | EP/X026833/1 | en_GB |
dc.identifier.grantnumber | 715884 | en_GB |
dc.identifier.grantnumber | MR/P01478X/1 | en_GB |
dc.identifier.grantnumber | EP/T017856/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/132785 | |
dc.identifier | ORCID: 0000-0002-8109-2765 (Wedgwood, Kyle CA) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.relation.url | https://github.com/dgalvis/network_spatial | en_GB |
dc.rights | © 2023 Galvis, Hodson and Wedgwood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.title | Spatial distribution of heterogeneity as a modulator of collective dynamics in pancreatic beta-cell networks and beyond | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-03-27T09:56:08Z | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record | en_GB |
dc.description | Data availability statement: The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: https://github.com/dgalvis/network_spatial | en_GB |
dc.identifier.eissn | 2674-0109 | |
dc.identifier.journal | Frontiers in Network Physiology | en_GB |
dc.relation.ispartof | Frontiers in Network Physiology, 3 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-03-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-03-24 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-03-27T09:51:22Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-03-27T09:56:11Z | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2023-03-24 |
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Except where otherwise noted, this item's licence is described as © 2023 Galvis, Hodson and Wedgwood. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.