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Fast dynamics in the HPA axis: Insight from mathematical and experimental studies

dc.contributor.authorWalker, JJ
dc.contributor.authorRomanò, N
dc.date.accessioned2023-09-26T06:48:19Z
dc.date.issued2022-08-18
dc.date.updated2023-09-25T20:29:48Z
dc.description.abstractThe activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterised by complex dynamics spanning several timescales. This ranges from slow circadian rhythms in blood hormone concentration to faster ultradian pulses of hormone secretion and even more rapid oscillations in electrical and calcium activity in neuroendocrine cells of the hypothalamus and pituitary gland. Here, we focus on the system's oscillations on the short timescale. We highlight some of the mathematical modelling and experimental work that has been carried out to characterise the mechanisms regulating this highly dynamic mode of neuroendocrine signalling and discuss some future directions that may be explored to enhance understanding of HPA function.en_GB
dc.description.sponsorshipMedical Research Council (MRC)en_GB
dc.identifier.citationVol. 27, article 100403en_GB
dc.identifier.doihttps://doi.org/10.1016/j.coemr.2022.100403
dc.identifier.grantnumberMR/N008936/1en_GB
dc.identifier.grantnumberMR/V012290/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/134086
dc.identifierORCID: 0000-0002-1952-8759 (Walker, Jamie J)
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/36632146en_GB
dc.rights© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_GB
dc.subjectACTHen_GB
dc.subjectAVPen_GB
dc.subjectCRHen_GB
dc.subjectCorticotrophen_GB
dc.subjectGlucocorticoiden_GB
dc.subjectHPA axisen_GB
dc.subjectModellingen_GB
dc.subjectOscillationen_GB
dc.subjectStressen_GB
dc.subjectUltradianen_GB
dc.titleFast dynamics in the HPA axis: Insight from mathematical and experimental studiesen_GB
dc.typeArticleen_GB
dc.date.available2023-09-26T06:48:19Z
exeter.article-number100403
exeter.place-of-publicationEngland
dc.descriptionThis is the final version. Available on open access from Elsevier via the DOI in this record. en_GB
dc.identifier.eissn2451-9650
dc.identifier.journalCurrent Opinion in Endocrine and Metabolic Researchen_GB
dc.relation.ispartofCurr Opin Endocr Metab Res, 27
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2022-08-18
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-09-26T06:42:05Z
refterms.versionFCDVoR
refterms.dateFOA2023-09-26T06:48:20Z
refterms.panelBen_GB
refterms.depositExceptionpublishedGoldOA


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© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's licence is described as © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).