Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations.
dc.contributor.author | Wei, C | |
dc.contributor.author | Vanhatalo, A | |
dc.contributor.author | Kadach, S | |
dc.contributor.author | Stoyanov, Z | |
dc.contributor.author | Abu-Alghayth, M | |
dc.contributor.author | Black, MI | |
dc.contributor.author | Smallwood, MJ | |
dc.contributor.author | Rajaram, R | |
dc.contributor.author | Winyard, PG | |
dc.contributor.author | Jones, AM | |
dc.date.accessioned | 2023-10-13T08:26:49Z | |
dc.date.issued | 2023-06-07 | |
dc.date.updated | 2023-10-12T14:57:54Z | |
dc.description.abstract | Dietary nitrate (NO3-) supplementation can enhance nitric oxide (NO) bioavailability and lower blood pressure (BP) in humans. The nitrite concentration ([NO2-]) in the plasma is the most commonly used biomarker of increased NO availability. However, it is unknown to what extent changes in other NO congeners, such as S-nitrosothiols (RSNOs), and in other blood components, such as red blood cells (RBC), also contribute to the BP lowering effects of dietary NO3-. We investigated the correlations between changes in NO biomarkers in different blood compartments and changes in BP variables following acute NO3- ingestion. Resting BP was measured and blood samples were collected at baseline, and at 1, 2, 3, 4 and 24 h following acute beetroot juice (∼12.8 mmol NO3-, ∼11 mg NO3-/kg) ingestion in 20 healthy volunteers. Spearman rank correlation coefficients were determined between the peak individual increases in NO biomarkers (NO3-, NO2-, RSNOs) in plasma, RBC and whole blood, and corresponding decreases in resting BP variables. No significant correlation was observed between increased plasma [NO2-] and reduced BP, but increased RBC [NO2-] was correlated with decreased systolic BP (rs = -0.50, P = 0.03). Notably, increased RBC [RSNOs] was significantly correlated with decreases in systolic (rs = -0.68, P = 0.001), diastolic (rs = -0.59, P = 0.008) and mean arterial pressure (rs = -0.64, P = 0.003). Fisher's z transformation indicated no difference in the strength of the correlations between increases in RBC [NO2-] or [RSNOs] and decreased systolic blood pressure. In conclusion, increased RBC [RSNOs] may be an important mediator of the reduction in resting BP observed following dietary NO3- supplementation. | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.description.sponsorship | China Scholarship Council | en_GB |
dc.format.extent | 1-9 | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 138-139, pp. 1-9 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.niox.2023.05.008 | |
dc.identifier.uri | http://hdl.handle.net/10871/134230 | |
dc.identifier | ORCID: 0000-0003-2546-5667 (Vanhatalo, Anni) | |
dc.identifier | ORCID: 0000-0001-9798-0612 (Black, Matthew I) | |
dc.identifier | ScopusID: 55580906100 (Black, Matthew I) | |
dc.identifier | ResearcherID: ABE-2880-2021 (Black, Matthew I) | |
dc.identifier | ORCID: 0000-0002-9613-1202 (Winyard, Paul G) | |
dc.identifier | ScopusID: 7005108335 (Winyard, Paul G) | |
dc.identifier | ResearcherID: B-6743-2011 (Winyard, Paul G) | |
dc.identifier | ORCID: 0000-0002-2082-1709 (Jones, Andrew M) | |
dc.identifier | ScopusID: 7407101756 (Jones, Andrew M) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37268184 | en_GB |
dc.rights | © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | Biomarkers | en_GB |
dc.subject | Nitric oxide | en_GB |
dc.subject | Plasma nitrite | en_GB |
dc.subject | Vascular tone | en_GB |
dc.title | Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-10-13T08:26:49Z | |
dc.identifier.issn | 1089-8603 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available from Elsevier via the DOI in this record. | en_GB |
dc.description | Data availability: Data will be made available on request. | en_GB |
dc.identifier.eissn | 1089-8611 | |
dc.identifier.journal | Nitric Oxide | en_GB |
dc.relation.ispartof | Nitric Oxide, 138-139 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-05-30 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-06-07 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-10-13T08:23:38Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-10-13T08:26:49Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-06-07 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).