Background: Prenatal caffeine exposure may influence offspring health via DNA
methylation (DNAm) but no large studies have tested this.
Materials & Methods: Epigenome-wide association studies and differentially
methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts ...
Background: Prenatal caffeine exposure may influence offspring health via DNA
methylation (DNAm) but no large studies have tested this.
Materials & Methods: Epigenome-wide association studies and differentially
methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts (n = 3742), Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea, and cola was compared to assess
whether caffeine is driving effects.
Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another
(cg14591243, STAG1) with cola intake. 12-22 DMRs were detected with limited overlap
across caffeinated beverages.
Conclusions: We found little evidence to support an intrauterine effect of caffeine on