Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis
dc.contributor.author | Schellhas, L | |
dc.contributor.author | Monasso, GS | |
dc.contributor.author | Felix, JF | |
dc.contributor.author | Jaddoe, VWV | |
dc.contributor.author | Huang, P | |
dc.contributor.author | Fernández-Barrés, S | |
dc.contributor.author | Vrijheid, M | |
dc.contributor.author | Pesce, G | |
dc.contributor.author | Annesi-Maesano, I | |
dc.contributor.author | Page, CM | |
dc.contributor.author | Brantsæter, A-L | |
dc.contributor.author | Bekkhus, M | |
dc.contributor.author | Håberg, SE | |
dc.contributor.author | London, S | |
dc.contributor.author | Munafò, MR | |
dc.contributor.author | Zuccolo, L | |
dc.contributor.author | Sharp, GC | |
dc.date.accessioned | 2023-11-02T15:38:22Z | |
dc.date.issued | 2023-11-29 | |
dc.date.updated | 2023-11-02T11:17:47Z | |
dc.description.abstract | Background: Prenatal caffeine exposure may influence offspring health via DNA methylation (DNAm) but no large studies have tested this. Materials & Methods: Epigenome-wide association studies and differentially methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts (n = 3742), Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea, and cola was compared to assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. 12-22 DMRs were detected with limited overlap across caffeinated beverages. Conclusions: We found little evidence to support an intrauterine effect of caffeine on | en_GB |
dc.identifier.citation | Vol. 15 (22), pp. 1179 - 1193 | en_GB |
dc.identifier.doi | 10.2217/epi-2023-0263 | |
dc.identifier.uri | http://hdl.handle.net/10871/134402 | |
dc.identifier | ORCID: 0000-0003-2906-4035 (Sharp, Gemma) | |
dc.language.iso | en | en_GB |
dc.publisher | Future Medicine | en_GB |
dc.rights | © 2023 The Authors. Open access. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | caffeine | en_GB |
dc.subject | pregnancy | en_GB |
dc.subject | offspring health | en_GB |
dc.subject | epigenetics | en_GB |
dc.subject | DNA methylation | en_GB |
dc.subject | PACE consortium | en_GB |
dc.title | Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-11-02T15:38:22Z | |
dc.identifier.issn | 1750-1911 | |
dc.description | This is the final version. Available on open access from Future Medicine via the DOI in this record | en_GB |
dc.identifier.journal | Epigenomics | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2023-11-02 | |
dcterms.dateSubmitted | 2023-07-20 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-11-02 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-11-02T11:17:52Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2024-01-17T16:23:11Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Open access. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/