Innovative Macula Capillaries Plexuses Visualization with OCTA B-Scan Graph Representation: Transforming OCTA B-Scan into OCTA Graph Representation
dc.contributor.author | Al-Hinnawi, A-R | |
dc.contributor.author | Al-Latayfeh, M | |
dc.contributor.author | Tavakoli, M | |
dc.date.accessioned | 2023-11-17T12:56:35Z | |
dc.date.issued | 2023-11-15 | |
dc.date.updated | 2023-11-16T20:54:01Z | |
dc.description.abstract | Purpose The aim of this study is to transform optical coherence tomography angiography (OCTA) scans into innovative OCTA graphs, serving as novel biomarkers representing the macular vasculature. Patients and Methods The study included 90 healthy subjects and 39 subjects with various abnormalities (29 with diabetic retinopathy, 5 with age-related macular degeneration, and 5 with choroid neovascularization). OCTA 5µm macular coronal views (MCVs) were generated for each subject, followed by blood vessel segmentation and skeleton processing. Subsequently, the blood vessel density index, blood vessel skeleton index, and blood vessel tortuosity index were computed. The graphs of each metric were plotted against the axial axes of the OCTA B-scan, representing the integrity of vasculature at successive 5µm macular depths. Results The results revealed two significant findings. First, the B-scans from OCTA can be transformed into OCTA graphs, yielding three specific OCTA graphs in this study. These graphs provide new biomarkers for assessing the integrity of deep vascular complex (DVC) and superficial vascular complex (SVC) within the macula. Second, a statistically significant difference was observed between normal (n=90) and abnormal (n=39) subjects, with a t-test p-value significantly lower than 0.001. The Mann–Whitney u-test also yielded significant difference but only between the 90 normal and 29 DR subjects. Conclusion The novel OCTA graphs offer a unique representation of the macula’s SVC and DVC, suggesting their potential in aiding physicians in the diagnosis of eye health within OCTA clinics. Further research is warranted to finalize the shape of these newly derived OCTA graphs and establish their clinical relevance and utility. | en_GB |
dc.format.extent | 3477-3491 | |
dc.identifier.citation | Vol. 16, pp. 3477-3491 | en_GB |
dc.identifier.doi | 10.2147/JMDH.S433405 | |
dc.identifier.uri | http://hdl.handle.net/10871/134574 | |
dc.identifier | ORCID: 0000-0003-2319-1543 (Tavakoli, Mitra) | |
dc.identifier | ScopusID: 16834120800 (Tavakoli, Mitra) | |
dc.identifier | ResearcherID: N-1402-2016 (Tavakoli, Mitra) | |
dc.language.iso | en | en_GB |
dc.publisher | Dove Medical Press Limited | en_GB |
dc.rights | © 2023 Al-Hinnawi et al. Open access. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | en_GB |
dc.subject | macula vasculature | en_GB |
dc.subject | medical imaging informatics | en_GB |
dc.subject | medical imaging processing procedures | en_GB |
dc.subject | optical coherence tomography angiography | en_GB |
dc.subject | vision science | en_GB |
dc.title | Innovative Macula Capillaries Plexuses Visualization with OCTA B-Scan Graph Representation: Transforming OCTA B-Scan into OCTA Graph Representation | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-11-17T12:56:35Z | |
dc.description | This is the final version. Available on open access from Dove Medical Press Limited via the DOI in this record | en_GB |
dc.identifier.eissn | 1178-2390 | |
dc.identifier.journal | Journal of Multidisciplinary Healthcare | en_GB |
dc.relation.ispartof | Journal of Multidisciplinary Healthcare, Volume 16 | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | en_GB |
dcterms.dateAccepted | 2023-11-01 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-11-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-11-17T12:54:26Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-11-17T12:56:40Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-11-15 |
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This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).