Plasma levels of PRO-C3, a type III collagen synthesis marker, are associated with arterial stiffness and increased risk of cardiovascular death
dc.contributor.author | Genovese, F | |
dc.contributor.author | Gonçalves, I | |
dc.contributor.author | Nielsen, SH | |
dc.contributor.author | Karsdal, MA | |
dc.contributor.author | Edsfeldt, A | |
dc.contributor.author | Nilsson, J | |
dc.contributor.author | Shore, AC | |
dc.contributor.author | Natali, A | |
dc.contributor.author | Khan, F | |
dc.contributor.author | Shami, A | |
dc.date.accessioned | 2023-12-21T14:58:39Z | |
dc.date.issued | 2023-12-10 | |
dc.date.updated | 2023-12-21T14:40:40Z | |
dc.description.abstract | Background and aims The N-terminal propeptide of type III collagen (PRO-C3) assay measures a pro-peptide released during type III collagen synthesis, an important feature of arterial stiffening and atherogenesis. There is a clinical need for improved non-invasive, cheap and easily accessible methods for evaluating individuals at risk of cardiovascular disease (CVD). In this study, we investigate the potential of using circulating levels of PRO-C3 to mark the degree of vascular stenosis and risk of cardiovascular events. Methods Baseline plasma levels of PRO-C3 were measured by ELISA in subjects belonging to the SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) cohort (N = 1354). Associations between PRO-C3 levels with vascular characteristics, namely stiffness and stenosis, and risk of future cardiovascular events were explored. Subjects were followed up after a median of 35 months (interquartile range 34–36 months), with recorded outcomes cardiovascular death and all-cause mortality. Results We found a correlation between PRO-C3 levels and pulse wave velocity (rho 0.13, p = 0.000009), a measurement of arterial stiffness. Higher PRO-C3 levels were also associated with elevated blood pressure (rho 0.07, p = 0.014), as well as risk of cardiovascular mortality over a three-year follow-up period (OR 1.56, confidence interval 1.008–2.43, p = 0.046). Conclusions Elevated circulating PRO-C3 levels are associated with arterial stiffness and future cardiovascular death, in the SUMMIT cohort, suggesting a potential value of PRO-C3 as a novel marker for declining vascular health. | en_GB |
dc.format.extent | 117420- | |
dc.identifier.citation | Vol. 388, article 117420 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.atherosclerosis.2023.117420 | |
dc.identifier.uri | http://hdl.handle.net/10871/134848 | |
dc.identifier | ORCID: 0000-0003-3039-308X (Shore, Angela C) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | en_GB |
dc.subject | Vascular stiffness | en_GB |
dc.subject | Hypertension | en_GB |
dc.subject | Atherosclerosis | en_GB |
dc.subject | Collagen | en_GB |
dc.title | Plasma levels of PRO-C3, a type III collagen synthesis marker, are associated with arterial stiffness and increased risk of cardiovascular death | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-12-21T14:58:39Z | |
dc.identifier.issn | 0021-9150 | |
exeter.article-number | 117420 | |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Atherosclerosis | en_GB |
dc.relation.ispartof | Atherosclerosis, 388 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-12-07 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-12-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-12-21T14:56:27Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-12-21T14:58:44Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)