Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study.
dc.contributor.author | Casanova, F | |
dc.contributor.author | O'Loughlin, J | |
dc.contributor.author | Karageorgiou, V | |
dc.contributor.author | Beaumont, RN | |
dc.contributor.author | Bowden, J | |
dc.contributor.author | Wood, AR | |
dc.contributor.author | Tyrrell, J | |
dc.date.accessioned | 2024-01-08T11:42:41Z | |
dc.date.issued | 2023-12-18 | |
dc.date.updated | 2024-01-08T08:37:24Z | |
dc.description.abstract | BACKGROUND: Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions. In this study, we use accelerometery-derived measures of PA and ST from the UK Biobank (UKB) and depression, anxiety and well-being data from the UKB mental health questionnaire as well as published summary statistics to explore the causal associations between these phenotypes. METHODS: We used MRlap to test if objectively measured PA and ST associate with mental health outcomes using UKB data and summary statistics from published genome-wide association studies. We also tested for bidirectional associations. We performed sex stratified as well as sensitivity analyses. RESULTS: Genetically instrumented higher PA was associated with lower odds of depression (OR = 0.92; 95% CI: 0.88, 0.97) and depression severity (beta = - 0.11; 95% CI: - 0.18, - 0.04), Genetically instrumented higher ST was associated higher odds of anxiety (OR = 2.59; 95% CI: 1.10, 4.60). PA was associated with higher well-being (beta = 0.11, 95% CI: 0.04; 0.18) and ST with lower well-being (beta = - 0.18; 95% CI: - 0.32, - 0.03). Similar findings were observed when stratifying by sex. There was evidence for a bidirectional relationship, with higher genetic liability to depression associated with lower PA (beta = - 0.25, 95% CI: - 0.42; - 0.08) and higher well-being associated with higher PA (beta = 0.15; 95% CI: 0.05, 0.25). CONCLUSIONS: We have demonstrated the bidirectional effects of both PA and ST on a range of mental health outcomes using objectively measured predictors and MR methods for causal inference. Our findings support a causal role for PA and ST in the development of mental health problems and in affecting well-being. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.format.extent | 501- | |
dc.format.medium | Electronic | |
dc.identifier.citation | Vol. 21, No. 1, article 501 | en_GB |
dc.identifier.doi | https://doi.org/10.1186/s12916-023-03211-z | |
dc.identifier.uri | http://hdl.handle.net/10871/134932 | |
dc.identifier | ORCID: 0000-0003-0275-4765 (Casanova, Francesco) | |
dc.identifier | ScopusID: 18436139700 | 56592223400 (Casanova, Francesco) | |
dc.identifier | ORCID: 0000-0003-0750-8248 (Beaumont, Robin N) | |
dc.identifier | ScopusID: 57156164500 (Beaumont, Robin N) | |
dc.identifier | ORCID: 0000-0003-2628-3304 (Bowden, Jack) | |
dc.identifier | ORCID: 0000-0002-9256-6065 (Tyrrell, Jessica) | |
dc.language.iso | en | en_GB |
dc.publisher | BMC | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38110912 | en_GB |
dc.rights | © The Author(s) 2023. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons. org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_GB |
dc.subject | Mendelian randomisation | en_GB |
dc.subject | Mental health | en_GB |
dc.subject | Physical activity | en_GB |
dc.subject | Well-being | en_GB |
dc.title | Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-01-08T11:42:41Z | |
dc.identifier.issn | 1741-7015 | |
exeter.article-number | 501 | |
exeter.place-of-publication | England | |
dc.description | Background: Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions. In this study, we use accelerometery-derived measures of PA and ST from the UK Biobank (UKB) and depression, anxiety and well-being data from the UKB mental health questionnaire as well as published summary statistics to explore the causal associations between these phenotypes. Methods: We used MRlap to test if objectively measured PA and ST associate with mental health outcomes using UKB data and summary statistics from published genome-wide association studies. We also tested for bidirectional associations. We performed sex stratified as well as sensitivity analyses. Results: Genetically instrumented higher PA was associated with lower odds of depression (OR = 0.92; 95% CI: 0.88, 0.97) and depression severity (beta = − 0.11; 95% CI: − 0.18, − 0.04), Genetically instrumented higher ST was associated higher odds of anxiety (OR = 2.59; 95% CI: 1.10, 4.60). PA was associated with higher well-being (beta = 0.11, 95% CI: 0.04; 0.18) and ST with lower well-being (beta = − 0.18; 95% CI: − 0.32, − 0.03). Similar findings were observed when stratifying by sex. There was evidence for a bidirectional relationship, with higher genetic liability to depression associated with lower PA (beta = − 0.25, 95% CI: − 0.42; − 0.08) and higher well-being associated with higher PA (beta = 0.15; 95% CI: 0.05, 0.25). Conclusions: We have demonstrated the bidirectional effects of both PA and ST on a range of mental health outcomes using objectively measured predictors and MR methods for causal inference. Our findings support a causal role for PA and ST in the development of mental health problems and in affecting well-being. | en_GB |
dc.identifier.journal | BMC Medicine | en_GB |
dc.relation.ispartof | BMC Med, 21(1) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-12-04 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-12-18 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-01-08T11:38:02Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-01-08T11:42:44Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-12-18 |
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regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this
licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.
org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.