Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results
dc.contributor.author | Dhanda, A | |
dc.contributor.author | Andrade, J | |
dc.contributor.author | Allende, H | |
dc.contributor.author | Allgar, V | |
dc.contributor.author | Bailey, M | |
dc.contributor.author | Callaghan, L | |
dc.contributor.author | Cocking, L | |
dc.contributor.author | Goodwin, E | |
dc.contributor.author | Hawton, A | |
dc.contributor.author | Hayward, C | |
dc.contributor.author | Hudson, B | |
dc.contributor.author | Ingram, W | |
dc.contributor.author | Jeffery, A | |
dc.contributor.author | King, A | |
dc.contributor.author | Lavers, V | |
dc.contributor.author | Lomax, J | |
dc.contributor.author | McCune, CA | |
dc.contributor.author | Musicha, C | |
dc.contributor.author | Parker, R | |
dc.contributor.author | Rollinson, C | |
dc.contributor.author | Wilks, J | |
dc.contributor.author | Creanor, ES | |
dc.date.accessioned | 2024-02-02T13:20:31Z | |
dc.date.issued | 2024-01-29 | |
dc.date.updated | 2024-02-02T11:23:15Z | |
dc.description.abstract | OBJECTIVE: The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether people with ARLD and AUD admitted to hospital could be recruited to and retained in a trial of Functional Imagery Training (FIT), a psychological therapy that uses mental imagery to reduce alcohol craving. We conducted a multicentre randomised pilot trial of treatment as usual (TAU) versus FIT+TAU in people admitted to hospital with ARLD and AUD. DESIGN: Participants were randomised to TAU (a single session of brief intervention) or FIT+TAU (TAU with one hospital-based FIT session then eight telephone sessions over 6 months). Pilot outcomes included recruitment rate and retention at day 180. Secondary outcomes included fidelity of FIT delivery, alcohol use, and severity of alcohol dependence. RESULTS: Fifty-four participants (mean age 49; 63% male) were recruited and randomised, 28 to TAU and 26 to FIT+TAU. The retention rate at day 180 was 43%. FIT was delivered adequately by most alcohol nurses. 50% of intervention participants completed FIT sessions 1 and 2. There were no differences in alcohol use or severity of alcohol dependence between treatment groups at day 180. CONCLUSION: Participants with ARLD and AUD could be recruited to a trial of FIT versus FIT+TAU. However, retention at day 180 was suboptimal. Before conducting a definitive trial of FIT in this patient group, modifications in the intervention and recruitment/retention strategy must be tested. TRIAL REGISTRATION NUMBER: ISRCTN41353774. | en_GB |
dc.description.sponsorship | Jon Moulton Charity Trust | en_GB |
dc.identifier.citation | Vol. 11, No. 1, article e001267 | en_GB |
dc.identifier.doi | https://doi.org/10.1136/bmjgast-2023-001267 | |
dc.identifier.uri | http://hdl.handle.net/10871/135227 | |
dc.identifier | ORCID: 0000-0002-7373-8263 (Creanor, E Siobhan) | |
dc.language.iso | en | en_GB |
dc.publisher | BMJ Publishing | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38286518 | en_GB |
dc.relation.url | http://hdl.handle.net/10871/130228 | |
dc.rights | © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dc.title | Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-02-02T13:20:31Z | |
dc.identifier.issn | 2054-4774 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from BMJ Publishing via the DOI in this record. | en_GB |
dc.description | Data availability statement: Data are available upon reasonable request. The trial protocol has been previously published. The statistical analysis plan is available in an online repository as referenced in the manuscript (https://pearl.plymouth.ac.uk). Data will be made available on contacting the corresponding author. | en_GB |
dc.description | The MIRAGE pilot trial protocol is available in ORE at http://hdl.handle.net/10871/130228 | |
dc.identifier.journal | BMJ Open Gastroenterology | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2024-01-04 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-01-29 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-02-02T13:15:49Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-02-02T13:20:36Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-01-29 |
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Except where otherwise noted, this item's licence is described as © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/