Whispering-Gallery Mode Optoplasmonic Microcavities: From Advanced Single-Molecule Sensors and Microlasers to Applications in Synthetic Biology
dc.contributor.author | Houghton, MC | |
dc.contributor.author | Kashanian, SV | |
dc.contributor.author | Derrien, TL | |
dc.contributor.author | Masuda, K | |
dc.contributor.author | Vollmer, F | |
dc.date.accessioned | 2024-02-05T12:55:03Z | |
dc.date.issued | 2024-02-03 | |
dc.date.updated | 2024-02-05T11:10:15Z | |
dc.description.abstract | Optical microcavities, specifically, whispering-gallery mode (WGM) microcavities, with their remarkable sensitivity to environmental changes, have been extensively employed as biosensors, enabling the detection of a wide range of biomolecules and nanoparticles. To push the limits of detection down to the most sensitive single-molecule level, plasmonic nanorods are strategically introduced to enhance the evanescent fields of WGM microcavities. This advancement of optoplasmonic WGM sensors allows for the detection of single molecules of a protein, conformational changes, and even atomic ions, marking significant contributions in single-molecule sensing. This Perspective discusses the exciting research prospects in optoplasmonic WGM sensing of single molecules, including the study of enzyme thermodynamics and kinetics, the emergence of thermo-optoplasmonic sensing, the ultrasensitive single-molecule sensing on WGM microlasers, and applications in synthetic biology. | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.identifier.citation | Published online 3 February 2024 | en_GB |
dc.identifier.doi | https://doi.org/10.1021/acsphotonics.3c01570 | |
dc.identifier.grantnumber | BB/T008741/1 | en_GB |
dc.identifier.grantnumber | EP/W013770/1 | en_GB |
dc.identifier.grantnumber | EP/R031428/1 | en_GB |
dc.identifier.grantnumber | EP/T002875/1 | en_GB |
dc.identifier.grantnumber | BB/Y512977/1 | en_GB |
dc.identifier.grantnumber | BB/V004166/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/135244 | |
dc.identifier | ORCID: 0000-0001-7570-6348 (Houghton, Matthew C) | |
dc.language.iso | en | en_GB |
dc.publisher | American Chemical Society (ACS) | en_GB |
dc.rights | © 2024 The Authors. Published by American Chemical Society. Open access. This publication is licensed under CC-BY 4.0 | en_GB |
dc.subject | enzymes | en_GB |
dc.subject | thermodynamics | en_GB |
dc.subject | whispering-gallery modes | en_GB |
dc.subject | optoplasmonics | en_GB |
dc.subject | plasmonics | en_GB |
dc.subject | optical microcavities | en_GB |
dc.title | Whispering-Gallery Mode Optoplasmonic Microcavities: From Advanced Single-Molecule Sensors and Microlasers to Applications in Synthetic Biology | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-02-05T12:55:03Z | |
dc.identifier.issn | 2330-4022 | |
dc.description | This is the final version. Available on open access from the American Chemical Society via the DOI in this record | en_GB |
dc.identifier.eissn | 2330-4022 | |
dc.identifier.journal | ACS Photonics | en_GB |
dc.relation.ispartof | ACS Photonics | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2024-01-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-02-03 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-02-05T12:52:07Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-02-05T12:55:09Z | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2024-02-03 |
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Except where otherwise noted, this item's licence is described as © 2024 The Authors. Published by American Chemical Society. Open access. This publication is licensed under CC-BY 4.0