Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations
dc.contributor.author | Méndez, JC | |
dc.contributor.author | Perry, BAL | |
dc.contributor.author | Premereur, E | |
dc.contributor.author | Pelekanos, V | |
dc.contributor.author | Ramadan, T | |
dc.contributor.author | Mitchell, AS | |
dc.date.accessioned | 2024-02-12T10:20:29Z | |
dc.date.issued | 2023-10-07 | |
dc.date.updated | 2024-02-11T20:53:21Z | |
dc.description.abstract | The control of some physiological parameters, such as the heart rate, is known to have a role in cognitive and emotional processes. Cardiac changes are also linked to mental health issues and neurodegeneration. Thus, it is not surprising that many of the brain structures typically associated with cognition and emotion also comprise a circuit-the central automatic network-responsible for the modulation of cardiovascular output. The mediodorsal thalamus (MD) is involved in higher cognitive processes and is also known to be connected to some of the key neural structures that regulate cardiovascular function. However, it is unclear whether the MD has any role in this circuitry. Here, we show that discrete manipulations (microstimulation during anaesthetized functional neuroimaging or localized cytotoxin infusions) to either the magnocellular or the parvocellular MD subdivisions led to observable and variable changes in the heart rate of female and male rhesus macaque monkeys. Considering the central positions that these two MD subdivisions have in frontal cortico-thalamocortical circuits, our findings suggest that MD contributions to autonomic regulation may interact with its identified role in higher cognitive processes, representing an important physiological link between cognition and emotion. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | FWO | en_GB |
dc.description.sponsorship | Cost Action Primtrain | en_GB |
dc.format.extent | 16913- | |
dc.format.medium | Electronic | |
dc.identifier.citation | Vol. 13, article 16913 | en_GB |
dc.identifier.doi | https://doi.org/10.1038/s41598-023-42752-4 | |
dc.identifier.grantnumber | WT 110157/Z/15/Z | en_GB |
dc.identifier.grantnumber | A15131 | en_GB |
dc.identifier.grantnumber | CA15131 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/135297 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37805650 | en_GB |
dc.rights | © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.title | Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-02-12T10:20:29Z | |
dc.identifier.issn | 2045-2322 | |
exeter.article-number | 16913 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from Nature Research via the DOI in this record | en_GB |
dc.description | Data availability; All data analysed during this study are included in this article. | en_GB |
dc.identifier.eissn | 2045-2322 | |
dc.identifier.journal | Scientific Reports | en_GB |
dc.relation.ispartof | Sci Rep, 13(1) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-09-14 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-10-07 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-02-12T10:10:30Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-02-12T10:20:37Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-10-07 |
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