Parkinson’s disease is a progressive neurodegenerative disorder, predominantly of the
motor system. Although some genetic components and cellular mechanisms of Parkinson’s have
been identified, much is still unknown. In recent years, emerging evidence has indicated that nonDNA-sequence variation (in particular epigenetic mechanisms) ...
Parkinson’s disease is a progressive neurodegenerative disorder, predominantly of the
motor system. Although some genetic components and cellular mechanisms of Parkinson’s have
been identified, much is still unknown. In recent years, emerging evidence has indicated that nonDNA-sequence variation (in particular epigenetic mechanisms) is likely to play a crucial role in the
development and progression of the disease. Here, we present an up-to-date overview of epigenetic
processes including DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs implicated in the brain of those with Parkinson’s disease. We will also discuss the
limitations of current epigenetic research in Parkinson’s disease, the advantages of simultaneously
studying genetics and epigenetics, and putative novel epigenetic therapies.
