New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Horikoshi, M; Yaghootkar, H; Mook-Kanamori, DO; et al.Sovio, U; Taal, HR; Hennig, BJ; Bradfield, JP; St Pourcain, B; Evans, David M.; Charoen, P; Kaakinen, M; Cousminer, DL; Lehtimäki, T; Kreiner-Møller, E; Warrington, NM; Bustamante, M; Feenstra, B; Berry, DJ; Thiering, E; Pfab, T; Barton, SJ; Shields, BM; Kerkhof, M; Van Leeuwen, EM; Fulford, AJ; Kutalik, Z; Zhao, JH; Den Hoed, M; Mahajan, A; Lindi, V; Goh, L-K; Hottenga, JJ; Wu, Y; Raitakari, OT; Harder, MN; Meirhaeghe, A; Ntalla, I; Salem, RM; Jameson, KA; Zhou, K; Monies, DM; Lagou, V; Kirin, M; Heikkinen, J; Adair, LS; Alkuraya, FS; Al-Odaib, A; Amouyel, P; Andersson, EA; Bennett, Amanda; Blakemore, AIF; Buxton, JL; Dallongeville, J; Das, S; de Geus, Eco; Estivill, X; Flexeder, C; Froguel, P; Geller, F; Godfrey, KM; Gottrand, F; Groves, Christopher J.; Hansen, T; Hirschhorn, JN; Hofman, A; Hollegaard, MV; Hougaard, DM; Hyppönen, E; Inskip, HM; Isaacs, A; Jørgensen, T; Kanaka-Gantenbein, C; Kemp, JP; Kiess, W; Kilpeläinen, TO; Klopp, N; Knight, BA; Kuzawa, CW; Mcmahon, G; Newnham, JP; Niinikoski, H; Oostra, BA; Pedersen, L; Postma, DS; Ring, SM; Rivadeneira, F; Robertson, NR; Sebert, S; Simell, O; Slowinski, T; Tiesler, CMT; Tönjes, A; Vaag, A; Viikari, JS; Vink, JM; Vissing, NH; Wareham, NJ; Willemsen, G; Witte, DR; Zhang, H; Zhao, J; Wilson, JF; Stumvoll, M; Prentice, AM; Meyer, BF; Pearson, ER; Boreham, CAG; Cooper, Cyrus; Gillman, MW; Dedoussis, George V.; Moreno, LA; Pedersen, O; Saarinen, M; Mohlke, KL; Boomsma, DI; Saw, S-M; Lakka, TA; Körner, A; Loos, RJF; Ong, KK; Vollenweider, P; Van Duijn, CM; Koppelman, GH; Hattersley, Andrew T.; Holloway, JW; Hocher, B; Heinrich, J; Power, C; Melbye, M; Guxens, M; Pennell, CE; Bønnelykke, K; Bisgaard, H; Eriksson, Johan G.; Widén, E; Hakonarson, H; Uitterlinden, AG; Pouta, A; Lawlor, DA; Smith, GD; Frayling, Timothy M.; McCarthy, MI; Grant, SFA; Jaddoe, VWV; Jarvelin, M-R; Timpson, NJ; Prokopenko, I; Freathy, RM
Date: 1 January 2013
Nature Publishing Group
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near ...
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Institute of Biomedical & Clinical Science
College of Medicine and Health
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